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- W407331356 abstract "There is debate about the existence of neuroendocrine cells in the normal breast, however, tumours with varying degrees of neuroendocrine differentiation occur. The latest WHO classification identifies solid neuroendocrine carcinoma, small and large cell carcinoma. In addition mucinous carcinoma contributes to a large number of tumours with neuroendocrine differentiation. The biology and molecular pathology of solid neuroendocrine and mucinous carcinomas do not appear independent of grade and these are generally low-grade lesions with an oestrogen receptor positive or negative, chromogranin A positive, TTF1 negative, molecular profile. Small and large cell carcinomas are aggressive tumours with often (but not always) an oestrogen receptor negative and chromogranin A positive, TTF1 positive profile. Metastasis of tumours with neuroendocrine attributes from elsewhere should always be considered when encountered in breast biopsy material." @default.
- W407331356 created "2016-06-24" @default.
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- W407331356 date "2009-01-01" @default.
- W407331356 modified "2023-09-26" @default.
- W407331356 title "Neuroendocrine Tumours of the Breast" @default.
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- W407331356 doi "https://doi.org/10.1007/978-1-60327-396-1_13" @default.
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