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- W407476645 abstract "Momordica charantia or bitter melon is widely used as traditional medicine for diabeticpatient. This study developed a statistical model in predicting the alpha-glucosidaseinhibitory activity of M. charantia fruit based on Fourier Transform Infrared Spectroscopy(FTIR). A total of six different ethanol extracts (0, 20, 40, 60, 80, and 100%) of this plantwere prepared. The chemical profiles of the extracts was conducted using FTIR spectroscopybetween 4000 and 600/cm at a resolution of 4/cm. Multivariate Data Analysis (MVDA) wasdeveloped by correlating the bioactivity and the third derivative FTIR spectra of eachindividual extract using Orthogonal Partial Least Square (OPLS). The result revealed that theregression coefficient (R2) between actual and predicted α-glucosidase inhibitory activitywas high (>0.80), and the standard error of prediction (SEP) and standard error of estimation(SEE) were acceptable. In conclusion, FTIR spectroscopy is a cheap and high-throughputtechnique that can be used as to predict the α-glucosidase inhibition activity of M. charantiafruit ." @default.
- W407476645 created "2016-06-24" @default.
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- W407476645 date "2014-12-03" @default.
- W407476645 modified "2023-09-24" @default.
- W407476645 title "Multivariate calibration of fourier transform infrared spectra in predicting anti-diabetic activity of momordica charantia fruit" @default.
- W407476645 hasPublicationYear "2014" @default.
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