FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W40771570> ?p ?o ?g. }

• W40771570 endingPage "111" @default.
• W40771570 startingPage "63" @default.
• W40771570 abstract "Ever since lysozyme was discovered by Fleming in 1922, this protein has emerged as a model for investigations on protein structure and function. Over the years, several high-resolution structures have yielded a wealth of structural data on this protein. Extensive studies on folding of lysozyme have shown how different regions of this protein dynamically interact with one another. Data is also available from numerous biotechnological studies wherein lysozyme has been employed as a model protein for recovering active recombinant protein from inclusion bodies using small molecules like l-arginine. A variety of conditions have been developed in vitro to induce fibrillation in hen lysozyme. They include (a) acidic pH at elevated temperature, (b) concentrated solutions of ethanol, (c) moderate concentrations of guanidinium hydrochloride at moderate temperature, and (d) alkaline pH at room temperature. This review aims to bring together similarities and differences in aggregation mechanisms, morphology of aggregates, and related issues that arise using the different conditions mentioned above to improve our understanding. The alkaline pH condition (pH 12.2), discovered and studied extensively in our lab, shall receive special attention. More than a decade ago, it was revealed that mutations in human lysozyme can cause accumulation of large quantities of amyloid in liver, kidney, and other regions of gastrointestinal tract. Understanding the mechanism of lysozyme aggregation will probably have therapeutic implications for the treatment of systemic nonneuropathic amyloidosis. Numerous studies have begun to focus attention on inhibition of lysozyme aggregation using antibody or small molecules. The enzymatic activity of lysozyme presents a convenient handle to quantify the native population of lysozyme in a sample where aggregation has been inhibited. The rich information available on lysozyme coupled with the multiple conditions that have been successful in inducing/inhibiting its aggregation in vitro makes lysozyme an ideal model protein to investigate amyloidogenesis." @default.
• W40771570 created "2016-06-24" @default.
• W40771570 creator A5022810871 @default.
• W40771570 creator A5027898641 @default.
• W40771570 creator A5056750587 @default.
• W40771570 creator A5065788627 @default.
• W40771570 creator A5091839656 @default.
• W40771570 date "2011-01-01" @default.
• W40771570 modified "2023-10-16" @default.
• W40771570 title "Lysozyme" @default.
• W40771570 cites W13307236 @default.
• W40771570 cites W145444268 @default.
• W40771570 cites W1486604732 @default.
• W40771570 cites W1489708565 @default.
• W40771570 cites W1497966777 @default.
• W40771570 cites W1500452426 @default.
• W40771570 cites W1519425272 @default.
• W40771570 cites W1541326863 @default.
• W40771570 cites W1544926311 @default.
• W40771570 cites W1546022138 @default.
• W40771570 cites W1591025537 @default.
• W40771570 cites W168587103 @default.
• W40771570 cites W1850804182 @default.
• W40771570 cites W1958422123 @default.
• W40771570 cites W1963996706 @default.
• W40771570 cites W1965353507 @default.
• W40771570 cites W1965890214 @default.
• W40771570 cites W1966913739 @default.
• W40771570 cites W1968064498 @default.
• W40771570 cites W1968194845 @default.
• W40771570 cites W1968788242 @default.
• W40771570 cites W1968998311 @default.
• W40771570 cites W1971071753 @default.
• W40771570 cites W1971509947 @default.
• W40771570 cites W1972373816 @default.
• W40771570 cites W1975373181 @default.
• W40771570 cites W1975445752 @default.
• W40771570 cites W1976335728 @default.
• W40771570 cites W1976632394 @default.
• W40771570 cites W1977802642 @default.
• W40771570 cites W1978781288 @default.
• W40771570 cites W1979038840 @default.
• W40771570 cites W1980825524 @default.
• W40771570 cites W1985121447 @default.
• W40771570 cites W1988176696 @default.
• W40771570 cites W1988598575 @default.
• W40771570 cites W1989048250 @default.
• W40771570 cites W1989419578 @default.
• W40771570 cites W1989984749 @default.
• W40771570 cites W1990818916 @default.
• W40771570 cites W1991349307 @default.
• W40771570 cites W1993676700 @default.
• W40771570 cites W1993791286 @default.
• W40771570 cites W1994774987 @default.
• W40771570 cites W1995075732 @default.
• W40771570 cites W1995151343 @default.
• W40771570 cites W1995747740 @default.
• W40771570 cites W1996112440 @default.
• W40771570 cites W1997713676 @default.
• W40771570 cites W1998951999 @default.
• W40771570 cites W1999660874 @default.
• W40771570 cites W2002559713 @default.
• W40771570 cites W2002608742 @default.
• W40771570 cites W2004630111 @default.
• W40771570 cites W2007535355 @default.
• W40771570 cites W2009870786 @default.
• W40771570 cites W2010477422 @default.
• W40771570 cites W2011881868 @default.
• W40771570 cites W2012455318 @default.
• W40771570 cites W2012467035 @default.
• W40771570 cites W2012596297 @default.
• W40771570 cites W2015184784 @default.
• W40771570 cites W2016382834 @default.
• W40771570 cites W2017784829 @default.
• W40771570 cites W2018842746 @default.
• W40771570 cites W2019456940 @default.
• W40771570 cites W2020377330 @default.
• W40771570 cites W2021957452 @default.
• W40771570 cites W2022513734 @default.
• W40771570 cites W2023665395 @default.
• W40771570 cites W2025404378 @default.
• W40771570 cites W2027293529 @default.
• W40771570 cites W2032664459 @default.
• W40771570 cites W2032689411 @default.
• W40771570 cites W2032920422 @default.
• W40771570 cites W2037768391 @default.
• W40771570 cites W2037857413 @default.
• W40771570 cites W2037866277 @default.
• W40771570 cites W2038268101 @default.
• W40771570 cites W2038938576 @default.
• W40771570 cites W2039484889 @default.
• W40771570 cites W2040312664 @default.
• W40771570 cites W2042548215 @default.
• W40771570 cites W2044788929 @default.
• W40771570 cites W2045182799 @default.
• W40771570 cites W2045524006 @default.
• W40771570 cites W2046350440 @default.
• W40771570 cites W2047404910 @default.

• next