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- W408202458 abstract "目的研究HER-2/neu(c-erbB-2)在卵巢上皮性肿瘤中的表达及意义.方法收集106例卵巢上皮性肿瘤(恶性54例,交界性33例,良性19例)及临床资料.按国际妇产科联合会(IGO)标准进行分期,卵巢癌中Ⅰ、Ⅱ期共19例(19/54,35.2%),Ⅲ、Ⅳ期共35例(35/54)64.8% ,交界性肿瘤均为Ⅰ期.采用标记链霉素卵白素生物素(LSAB)法用HER-2/neu多克隆抗体(DAKO,A0485)行免疫组织化学染色.结果该蛋白表达的阳性率在良性肿瘤为47.4%(9/19),过表达(3+)为0;交界性肿瘤为84.8%(28/33),过表达率为9.1%(3/33);恶性肿瘤为85.2%(46/54),过表过率为25.9%(14/57).良性与交界性以及良性与恶性之间的HER-2/neu蛋白表达率的差异有显著性(P＜0.02,P＜0.01);该蛋白的过表达率在有转移和无转移的病例之间差异有显著性意义(P＜0.001).结论HER-2/neu的过表达与卵巢癌的侵袭性生物学行为相关." @default.
- W408202458 created "2016-06-24" @default.
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- W408202458 date "2002-06-08" @default.
- W408202458 modified "2023-09-25" @default.
- W408202458 title "HER-2/neu在卵巢上皮性肿瘤中的表达及意义" @default.
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