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- W40906279 abstract "AIM: To investigate the molecular mechanism of HepG2 cell apoptosis induced by Taurodeoxycholic acid (TDCA). METHODS: Morphologic evaluations of apoptosis were performed by HE staining and electro-microscope. DNA fragment was detected by electrophoresis on 1.5 % agarose gel. Apoptosis rate was measured by flow cytometry using PI probe. After incubation of HepG2 cell with TDCA, the release of cytochrome C from mitochondria into cytosol was determined by Western blot analysis, and the activitives of Caspase-8,9,3 were evaluated by chrolometry. RESULTS: Incubation of HepG2 cells with 400 μmol/L TDCA for 12 h induced significant cell apoptosis. Flow cytometry analysis showed that apoptosis rate was 50.4±2.2 % following TDCA incubation. The release of cytochrome C from mitochondria to cytosol in a time-dependent pattern was demonstrated during the development of apoptosis with subsequent activation of Caspase-9 and 3 obviously, while the activation of Caspase-8 was slightly involved in this apoptotic pathway. CONCLUSION: TDCA can induce cell apoptosis mainly through initiating the release of cytochrome C from mitochondria to cytosol and the subsequent activation of procaspase-9. Li GM, Xie Q, Zhou XQ, Yu H, Guo Q, Liao D, Li DG. Taurodeoxycholic acid induced apoptosis via mitochondrial injury in HepG2 cells.Shijie Huaren Xiaohua Zazhi 2003;11(8):1148-1151 摘要 目的: 探讨牛磺酸脱氧胆酸(TDCA)诱导HepG2细胞凋亡的" @default.
- W40906279 created "2016-06-24" @default.
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- W40906279 date "2003-08-15" @default.
- W40906279 modified "2023-10-02" @default.
- W40906279 title "Taurodeoxycholic acid induced apoptosis via mitochondrial injury in HepG2 cells" @default.
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- W40906279 doi "https://doi.org/10.11569/wcjd.v11.i8.1148" @default.
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