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- W409295466 abstract "OBJECTIVE: to investigate longitudinal cerebral white matter damage in patients with amyotrophic lateral sclerosis (ALS).BACKGROUND: ALS is a devastating neurodegerative disorder of motor neurons. Prognostic biomarkers are needed in ALS, and MRI parameters are a promising candidate, particularly those related to the integrity of white matter tracts.DESIGN/METHODS: We enrolled 24 patients (mean age 47.9±14.1, 15 men) that were evaluated at baseline and after six months of follow-up. We used the Revised ALS Functional Rating Scale (ALSFRS-S) to quantify disease severity. All subjects underwent MRI and diffusion tensor imaging sequences (DTI) were used to assess WM abnormalities. DTI data were evaluated through tract-based spatial statistics (TBSS) and the group analysis was performed using a paired t-test. All results were corrected for multiple comparisons and the John Hopkins white matter DTI based atlas was used to identified fiber tracts.RESULTS: Mean ALSFRS-S score and disease duration in the first visit were 33.6±8.81 and 43.6±32.5 months, respectively. Longitudinal TBSS revealed progressive microstructural abnormalities at the corpus callosum regarding mean diffusivity and axial diffusivity. In addition, we found increased axial diffusivity at the medial portion of the right pyramidal tract.CONCLUSIONS: There is progressive callosal microstructural damage in ALS amenable to detection in a short-term follow-up. DTI-based parameters of the corpus Callosum are promising neuroimaging markers for the disease.Study Supported by:CAPES, FAPESP Disclosure: Dr. Albuquerque has nothing to disclose. Dr. Rezende has nothing to disclose. Dr. Andrade has nothing to disclose. Dr. Nucci has nothing to disclose. Dr. Franca, Jr. has nothing to disclose." @default.
- W409295466 created "2016-06-24" @default.
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- W409295466 date "2015-04-06" @default.
- W409295466 modified "2023-10-02" @default.
- W409295466 title "Progressive Callosal Damage In Amyotrophic Lateral Sclerosis (P2.060)" @default.
- W409295466 hasPublicationYear "2015" @default.
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