Matches in SemOpenAlex for { <https://semopenalex.org/work/W40937328> ?p ?o ?g. }
- W40937328 endingPage "332" @default.
- W40937328 startingPage "329" @default.
- W40937328 abstract "Genetic polymorphisms in plasminogen activator inhibitor-1 gene-675 4G/5G (PAI-1 4G/5G) are claimed to contribute to an increased risk of venous thromboembolism. Inherited thrombophilia, on the other hand, is associated with the occurrence of spontaneous abortions. The objective of this study was, to explore the significance of genetic polymorphisms of PAI-1 4G/5G with particular emphasis on 4G alleles in pregnant women suffering from venous thromboembolism or early spontaneous abortion, respectively. Therefore genetic PAI-1 4G/5G polymorphisms were studied in 108 pregnant females suffering from venous thromboembolism (n=69) or from spontaneous abortion (<20 week, n=39), respectively. Healthy volunteers (n=238) were taken as controls. The frequencies of 4G alleles (4G/4G or 4G/5G genotypes) of PAI-1 were significantly higher in venous thromboembolism (OR: 3.40, p=0.0088) and slightly higher, but not significantly, in abortions (RR: 2.33; p=0.1162) compared to controls. The incidence of 4G-carriers in females with abortion was 0.68 (-32%) compared to women suffering from venous thromboembolism alone. We conclude from these data, that the occurrence of PAI-1 4G/4G or 4G/5G genotypes, respectively, is clinically significant for the pathogenesis of venous thromboembolism in pregnancy but not for early abortion." @default.
- W40937328 created "2016-06-24" @default.
- W40937328 creator A5005745918 @default.
- W40937328 creator A5020700949 @default.
- W40937328 creator A5027700446 @default.
- W40937328 creator A5060947872 @default.
- W40937328 creator A5070217079 @default.
- W40937328 date "2008-01-01" @default.
- W40937328 modified "2023-10-14" @default.
- W40937328 title "Comparison of the plasminogen activator inhibitor-1 4G/5G gene polymorphism in females with venous thromboembolism during pregnancy or spontaneous abortion" @default.
- W40937328 cites W11409187 @default.
- W40937328 cites W1445101152 @default.
- W40937328 cites W1827717021 @default.
- W40937328 cites W1973651646 @default.
- W40937328 cites W1987540300 @default.
- W40937328 cites W2006049280 @default.
- W40937328 cites W2010855729 @default.
- W40937328 cites W2024109963 @default.
- W40937328 cites W2027416045 @default.
- W40937328 cites W2038158926 @default.
- W40937328 cites W2048649139 @default.
- W40937328 cites W2068531894 @default.
- W40937328 cites W2087418556 @default.
- W40937328 cites W2088325301 @default.
- W40937328 cites W2088954183 @default.
- W40937328 cites W2091117299 @default.
- W40937328 cites W2103886741 @default.
- W40937328 cites W2117814062 @default.
- W40937328 cites W2120352427 @default.
- W40937328 cites W2122774674 @default.
- W40937328 doi "https://doi.org/10.3233/ch-2008-1098" @default.
- W40937328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18503142" @default.
- W40937328 hasPublicationYear "2008" @default.
- W40937328 type Work @default.
- W40937328 sameAs 40937328 @default.
- W40937328 citedByCount "12" @default.
- W40937328 countsByYear W409373282013 @default.
- W40937328 countsByYear W409373282014 @default.
- W40937328 countsByYear W409373282015 @default.
- W40937328 countsByYear W409373282016 @default.
- W40937328 countsByYear W409373282020 @default.
- W40937328 countsByYear W409373282023 @default.
- W40937328 crossrefType "journal-article" @default.
- W40937328 hasAuthorship W40937328A5005745918 @default.
- W40937328 hasAuthorship W40937328A5020700949 @default.
- W40937328 hasAuthorship W40937328A5027700446 @default.
- W40937328 hasAuthorship W40937328A5060947872 @default.
- W40937328 hasAuthorship W40937328A5070217079 @default.
- W40937328 hasConcept C104317684 @default.
- W40937328 hasConcept C126322002 @default.
- W40937328 hasConcept C131872663 @default.
- W40937328 hasConcept C135763542 @default.
- W40937328 hasConcept C149737253 @default.
- W40937328 hasConcept C180754005 @default.
- W40937328 hasConcept C2778642596 @default.
- W40937328 hasConcept C2779234561 @default.
- W40937328 hasConcept C2779679481 @default.
- W40937328 hasConcept C2780011451 @default.
- W40937328 hasConcept C2780675426 @default.
- W40937328 hasConcept C2780842393 @default.
- W40937328 hasConcept C2780868729 @default.
- W40937328 hasConcept C2780942790 @default.
- W40937328 hasConcept C29456083 @default.
- W40937328 hasConcept C2991741193 @default.
- W40937328 hasConcept C54355233 @default.
- W40937328 hasConcept C71924100 @default.
- W40937328 hasConcept C86803240 @default.
- W40937328 hasConcept C90924648 @default.
- W40937328 hasConceptScore W40937328C104317684 @default.
- W40937328 hasConceptScore W40937328C126322002 @default.
- W40937328 hasConceptScore W40937328C131872663 @default.
- W40937328 hasConceptScore W40937328C135763542 @default.
- W40937328 hasConceptScore W40937328C149737253 @default.
- W40937328 hasConceptScore W40937328C180754005 @default.
- W40937328 hasConceptScore W40937328C2778642596 @default.
- W40937328 hasConceptScore W40937328C2779234561 @default.
- W40937328 hasConceptScore W40937328C2779679481 @default.
- W40937328 hasConceptScore W40937328C2780011451 @default.
- W40937328 hasConceptScore W40937328C2780675426 @default.
- W40937328 hasConceptScore W40937328C2780842393 @default.
- W40937328 hasConceptScore W40937328C2780868729 @default.
- W40937328 hasConceptScore W40937328C2780942790 @default.
- W40937328 hasConceptScore W40937328C29456083 @default.
- W40937328 hasConceptScore W40937328C2991741193 @default.
- W40937328 hasConceptScore W40937328C54355233 @default.
- W40937328 hasConceptScore W40937328C71924100 @default.
- W40937328 hasConceptScore W40937328C86803240 @default.
- W40937328 hasConceptScore W40937328C90924648 @default.
- W40937328 hasIssue "1–4" @default.
- W40937328 hasLocation W409373281 @default.
- W40937328 hasLocation W409373282 @default.
- W40937328 hasOpenAccess W40937328 @default.
- W40937328 hasPrimaryLocation W409373281 @default.
- W40937328 hasRelatedWork W1994784089 @default.
- W40937328 hasRelatedWork W2042693310 @default.
- W40937328 hasRelatedWork W2103842148 @default.
- W40937328 hasRelatedWork W2358186839 @default.
- W40937328 hasRelatedWork W2367195585 @default.