FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W40969440> ?p ?o ?g. }

• W40969440 abstract "The ability of conducting polymers such as poly(3,4-ethylenedioxythiophene) (PEDOT) to store a drug as a dopant and release it following electrical stimulus make them an intriguing coating possibility for intracortical electrodes, along with their ability to reduce electrode impedance. The mechanism allows for the release of an assortment of useful agents, including anti-inflammatory drugs and neuromodulatory chemicals. We evaluated the release capabilities of a multi-walled carbon nanotube (MWCNT)-doped PEDOT coating incorporating the anti-inflammatory steroid dexamethasone in vitro using sputtered-gold macroelectrodes, and then applied the coating to half of the electrodes within 16-shank platinum/iridium floating microelectrode arrays for chronic in vivo evaluation in rat visual cortex. Impedance measurement, neurophysiological recording, and cyclic voltammetric release stimulus (-0.9 V to 0.6 V, 1 V/s, 20 cycles) was performed daily to all channels. On the 11th day, histology was performed to quantitatively characterize inflammatory tissue response using OX42 (microglia) and GFAP (astroglia). Equivalent circuit analysis was performed to assist the interpretation of impedance data. Our results indicated that the MWCNT/PEDOT-coated gold macroelectrodes released double the amount of dexamethasone using passive release followed by CV stimulation (10 sets of 20 cycles) compared to passive release alone. Coatings applied to Pt/Ir microelectrodes reduced 1 kHz impedance in PBS by approximately 38%. Coated probes in vivo exhibited a significant decrease in 1 kHz impedance for the initial three days of implantation followed by an increase, between days 4 and 7, to values equivalent to those exhibited by uncoated probes. Neurophysiological recording performance of coated and uncoated probes remained equivalent for the duration of the experiment, in terms of signal-to-noise ratio and noise amplitude. Histology revealed no significant difference in tissue inflammatory response to coated and uncoated electrodes. Explant imaging revealed the presence of a membranous film enveloping coated electrodes, and equivalent circuit analysis suggested that the day 4-7 increase in 1 kHz impedance of coated electrodes was due to a decrease in effective surface area of the coatings as well as the core electrodes. Additional work was also performed developing a model for the in vivo microinjection of the enzyme Chondroitinase ABC into tissue surrounding implanted microelectrodes." @default.
• W40969440 created "2016-06-24" @default.
• W40969440 creator A5044030473 @default.
• W40969440 date "2013-01-01" @default.
• W40969440 modified "2023-09-26" @default.
• W40969440 title "The degradation of glial scar and enhancement of chronic intracortical recording electrode performance through the local delivery of dexamethasone and chondroitinase" @default.
• W40969440 cites W1484827186 @default.
• W40969440 cites W1485992312 @default.
• W40969440 cites W1558038422 @default.
• W40969440 cites W1765293499 @default.
• W40969440 cites W186946218 @default.
• W40969440 cites W1904639934 @default.
• W40969440 cites W1910147314 @default.
• W40969440 cites W1964380577 @default.
• W40969440 cites W1964919865 @default.
• W40969440 cites W1966007526 @default.
• W40969440 cites W1966365325 @default.
• W40969440 cites W1966551174 @default.
• W40969440 cites W1967575106 @default.
• W40969440 cites W1967667427 @default.
• W40969440 cites W1969870305 @default.
• W40969440 cites W1970746499 @default.
• W40969440 cites W1970901436 @default.
• W40969440 cites W1971469691 @default.
• W40969440 cites W1971668430 @default.
• W40969440 cites W1972666377 @default.
• W40969440 cites W1972966292 @default.
• W40969440 cites W1973677172 @default.
• W40969440 cites W1975118873 @default.
• W40969440 cites W1975669290 @default.
• W40969440 cites W1975975754 @default.
• W40969440 cites W1978157854 @default.
• W40969440 cites W1978328220 @default.
• W40969440 cites W1978562671 @default.
• W40969440 cites W1981823135 @default.
• W40969440 cites W1983035812 @default.
• W40969440 cites W1985273119 @default.
• W40969440 cites W1985829219 @default.
• W40969440 cites W1986885950 @default.
• W40969440 cites W1988649470 @default.
• W40969440 cites W1988733601 @default.
• W40969440 cites W1989403232 @default.
• W40969440 cites W1989927577 @default.
• W40969440 cites W1990930019 @default.
• W40969440 cites W1991458644 @default.
• W40969440 cites W1992142582 @default.
• W40969440 cites W1992572371 @default.
• W40969440 cites W1994641975 @default.
• W40969440 cites W1995063875 @default.
• W40969440 cites W1995283736 @default.
• W40969440 cites W1996271201 @default.
• W40969440 cites W1996291059 @default.
• W40969440 cites W1997105336 @default.
• W40969440 cites W1998483724 @default.
• W40969440 cites W1999053642 @default.
• W40969440 cites W1999201911 @default.
• W40969440 cites W1999733628 @default.
• W40969440 cites W1999941576 @default.
• W40969440 cites W2001477745 @default.
• W40969440 cites W2001702704 @default.
• W40969440 cites W2003397788 @default.
• W40969440 cites W2003438800 @default.
• W40969440 cites W2003674452 @default.
• W40969440 cites W2003726233 @default.
• W40969440 cites W2005378461 @default.
• W40969440 cites W2007719782 @default.
• W40969440 cites W2008921519 @default.
• W40969440 cites W2009882479 @default.
• W40969440 cites W2011745605 @default.
• W40969440 cites W2012385437 @default.
• W40969440 cites W2012928251 @default.
• W40969440 cites W2012980852 @default.
• W40969440 cites W2014714591 @default.
• W40969440 cites W2014958857 @default.
• W40969440 cites W2015785599 @default.
• W40969440 cites W2015911868 @default.
• W40969440 cites W2017010419 @default.
• W40969440 cites W2017469060 @default.
• W40969440 cites W2017742181 @default.
• W40969440 cites W2017847893 @default.
• W40969440 cites W2018371812 @default.
• W40969440 cites W2019397808 @default.
• W40969440 cites W2020769260 @default.
• W40969440 cites W2022962051 @default.
• W40969440 cites W2023969516 @default.
• W40969440 cites W2024641423 @default.
• W40969440 cites W2026100867 @default.
• W40969440 cites W2027127149 @default.
• W40969440 cites W2028805384 @default.
• W40969440 cites W2029527028 @default.
• W40969440 cites W2030066709 @default.
• W40969440 cites W2030927825 @default.
• W40969440 cites W2031364138 @default.
• W40969440 cites W2031930458 @default.
• W40969440 cites W2034289055 @default.
• W40969440 cites W2035418483 @default.
• W40969440 cites W2036320641 @default.
• W40969440 cites W2036472881 @default.
• W40969440 cites W2036742353 @default.
• W40969440 cites W2037866782 @default.

• next