FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W410947787> ?p ?o ?g. }

• W410947787 endingPage "38" @default.
• W410947787 startingPage "24" @default.
• W410947787 abstract "Dendritic cells (DCs) are key regulators of host immunity that are capable of inducing either immune tolerance or activation. In addition to their well-characterized role in shaping immune responses to foreign pathogens, DCs are also known to be critical for the induction and maintenance of anti-tumor immune responses. Therefore, it is important to understand how tumors influence the function of DCs and the quality of immune responses they elicit. Although the majority of studies in this field to date have utilized either immortalized DC lines or DC populations that have been generated under artificial conditions from hematopoietic precursors in vitro, we wished to investigate how tumors impact the function of already differentiated, tissue-resident DCs. Therefore, we used both an ex vivo and in vivo model system to assess the influence of melanoma-derived factors on DC maturation and activation. In ex vivo studies with freshly isolated splenic DCs, we demonstrate that the extent to which DC maturation and activation are altered by these factors correlates with melanoma tumorigenicity, and we identify partial roles for tumor-derived transforming growth factor (TGF)β1 and vascular endothelial growth factor (VEGF)-A in the altered functionality of DCs. In vivo studies using a lung metastasis model of melanoma also demonstrate tumorigenicity-dependent alterations to the function of lung-resident DCs, and skewed production of proinflammatory cytokines and chemokines by these tumor-altered cells is associated with recruitment of an immune infiltrate that may ultimately favor tumor immune escape and outgrowth." @default.
• W410947787 created "2016-06-24" @default.
• W410947787 creator A5006716688 @default.
• W410947787 creator A5009115733 @default.
• W410947787 creator A5017144217 @default.
• W410947787 creator A5049146308 @default.
• W410947787 creator A5070012406 @default.
• W410947787 creator A5091349663 @default.
• W410947787 date "2015-06-16" @default.
• W410947787 modified "2023-09-27" @default.
• W410947787 title "Melanoma‐derived factors alter the maturation and activation of differentiated tissue‐resident dendritic cells" @default.
• W410947787 cites W120314612 @default.
• W410947787 cites W1483271435 @default.
• W410947787 cites W1521600055 @default.
• W410947787 cites W1528268074 @default.
• W410947787 cites W1534491890 @default.
• W410947787 cites W1548995508 @default.
• W410947787 cites W1563336787 @default.
• W410947787 cites W1575865260 @default.
• W410947787 cites W1585754595 @default.
• W410947787 cites W1661544713 @default.
• W410947787 cites W1678477267 @default.
• W410947787 cites W1847382019 @default.
• W410947787 cites W1933156295 @default.
• W410947787 cites W193748226 @default.
• W410947787 cites W1964223023 @default.
• W410947787 cites W1967577151 @default.
• W410947787 cites W1969327218 @default.
• W410947787 cites W1970555184 @default.
• W410947787 cites W1978586979 @default.
• W410947787 cites W1992384164 @default.
• W410947787 cites W1995116853 @default.
• W410947787 cites W2002801575 @default.
• W410947787 cites W2002811765 @default.
• W410947787 cites W2003559866 @default.
• W410947787 cites W2014986361 @default.
• W410947787 cites W2033200817 @default.
• W410947787 cites W2037571710 @default.
• W410947787 cites W2038481383 @default.
• W410947787 cites W2041600831 @default.
• W410947787 cites W2043398751 @default.
• W410947787 cites W2054184733 @default.
• W410947787 cites W2061628667 @default.
• W410947787 cites W2066469619 @default.
• W410947787 cites W2071776361 @default.
• W410947787 cites W2077773656 @default.
• W410947787 cites W2090177390 @default.
• W410947787 cites W2092626661 @default.
• W410947787 cites W2095956223 @default.
• W410947787 cites W2096216039 @default.
• W410947787 cites W2098020683 @default.
• W410947787 cites W2102689053 @default.
• W410947787 cites W2103840609 @default.
• W410947787 cites W2107456313 @default.
• W410947787 cites W2109663505 @default.
• W410947787 cites W2110651507 @default.
• W410947787 cites W2118863472 @default.
• W410947787 cites W2129630141 @default.
• W410947787 cites W2132929600 @default.
• W410947787 cites W2133062667 @default.
• W410947787 cites W2133449490 @default.
• W410947787 cites W2143565660 @default.
• W410947787 cites W2154685907 @default.
• W410947787 cites W2156613396 @default.
• W410947787 cites W2157269800 @default.
• W410947787 cites W2158500407 @default.
• W410947787 cites W2159133324 @default.
• W410947787 cites W2163825883 @default.
• W410947787 cites W2166891849 @default.
• W410947787 cites W2275872217 @default.
• W410947787 cites W3112156481 @default.
• W410947787 doi "https://doi.org/10.1038/icb.2015.58" @default.
• W410947787 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26010746" @default.
• W410947787 hasPublicationYear "2015" @default.
• W410947787 type Work @default.
• W410947787 sameAs 410947787 @default.
• W410947787 citedByCount "38" @default.
• W410947787 countsByYear W4109477872015 @default.
• W410947787 countsByYear W4109477872016 @default.
• W410947787 countsByYear W4109477872017 @default.
• W410947787 countsByYear W4109477872018 @default.
• W410947787 countsByYear W4109477872019 @default.
• W410947787 countsByYear W4109477872020 @default.
• W410947787 countsByYear W4109477872021 @default.
• W410947787 countsByYear W4109477872022 @default.
• W410947787 countsByYear W4109477872023 @default.
• W410947787 crossrefType "journal-article" @default.
• W410947787 hasAuthorship W410947787A5006716688 @default.
• W410947787 hasAuthorship W410947787A5009115733 @default.
• W410947787 hasAuthorship W410947787A5017144217 @default.
• W410947787 hasAuthorship W410947787A5049146308 @default.
• W410947787 hasAuthorship W410947787A5070012406 @default.
• W410947787 hasAuthorship W410947787A5091349663 @default.
• W410947787 hasConcept C109159458 @default.
• W410947787 hasConcept C13373296 @default.
• W410947787 hasConcept C150903083 @default.
• W410947787 hasConcept C164027704 @default.
• W410947787 hasConcept C203014093 @default.

• next