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- W41102453 abstract "Conventional clinical and radiological methods do not detect metastasis in a large majority of patients. It is accepted that this group of patients mayhave micrometastatic disease at presentation. The lymphovascular function of the marrow represents an ideal location to detect micrometastasis. Various immunological methods have been used to detect micrometastases. Immunochemical staining using specific polyclonal or monoclonal antibodies singly or in combination, specific for epithelial-derived cell membrane antigens yield high sensitivity in ability to detect cancer cells in bone marrow. Immunocytochemistry can detect approximately 2.5 cancer cells per 1×106 normal bone marrow cells. The number of micrometastatic cells detected in bone marrow may be a measure of thesystemic tumour cell burden. The majority of studies suggest that the presence and number of breast cancer micrometastases in the bone marrow predicts early distant relapse. The characteristics of the primary tumour that correlate with bone marrow micrometastases require further investigation.Key wordsBone marrow micrometastasesimmunocytochemistrybreast carcinomaRT-PCR" @default.
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- W41102453 date "2006-01-10" @default.
- W41102453 modified "2023-09-24" @default.
- W41102453 title "Bone Marrow Micrometastases Detection and Significance" @default.
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- W41102453 doi "https://doi.org/10.1007/0-306-48388-2_8" @default.
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