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- W41205199 abstract "Intrinsic resistance to both chemotherapy and radiotherapy remains a major obstacle in the clinical treatment of malignant melanoma. Recent advances in cancer research have provided new insights into the molecular mechanisms governing their intrinsic resistance. We have recently demonstrated that DOPAchrome tautomerase (DCT), an enzyme that is well characterized for its function in melanin synthesis, is highly expressed in human melanoma cells that are resistant to both drug and radiation treatments. Conversely, melanoma cells expressing very low levels of DCT are highly susceptible to either type of treatment. Overexpression of DCT in melanoma cells by transfection could confer both radioresistance and chemoresistance. This review will summarize our findings, as well as discuss the possible mechanisms by which DCT overexpression contributes to intrinsic resistance of human malignant melanoma." @default.
- W41205199 created "2016-06-24" @default.
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- W41205199 date "2007-11-04" @default.
- W41205199 modified "2023-09-25" @default.
- W41205199 title "The Role of DCT/TYRP2 in Resistance of Melanoma Cells to Drugs and Radiation" @default.
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- W41205199 doi "https://doi.org/10.1007/978-1-59259-994-3_32" @default.
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