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- W41234546 abstract "Dermal delivery for the treatment of skin disorders offers numerous potential advantages over conventional therapies including avoidance of hepatic first-pass metabolism, improved patient compliance, lower systemic absorption and reduced side effects. Previous studies by the authors have shown that hyaluronan (HA) is more effective than other gel-forming materials in localising the delivery of radiolabelled diclofenac within the epidermis of human skin. Such phenomena have also been reported in vivo in both mice and humans and have helped to facilitate the regulatory approval of a topical HA/diclofenac formulation for the treatment of actinic keratosis. However, a mechanism of action to explain the topical delivery properties of HA remains to be elucidated. The aim of this study was to compare the effect of HA with other glycosaminoglycans and pharmaceutically relevant polysaccharides on the thermodynamic activity and percutaneous penetration of diclofenac and ibuprofen.The dermal partitioning of diclofenac and ibuprofen in various concentrations of HA, chondroitin sulphate (CS), heparin (HP), sodium carboxymethyl cellulose (NaCMC) and pectin were determined. The results from these studies were then compared to Franz cell skin deposition studies.The studies demonstrated that HA significantly enhanced the partitioning of both diclofenac and ibuprofen into human skin when compared to an aqueous control, pectin and CMC (p 0.05). Results from the Franz cell diffusion studies showed that HA (1% w/w) significantly enhanced the amount of drug localising within the epidermis after 24 h when compared to an aqueous control (p<0.01), PT (p0.01), CMC (p<0.01) and CS (p<0.05).The results suggest that glycosaminoglycans may promote the partitioning of certain drugs into human skin but only HA could be shown to significantly affect the overall intradermal localisation after 48 h of application. Thus, the inclusion of hyaluronan as a vehicle excipient offers clear potential in the dermal delivery and localisation of drugs." @default.
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- W41234546 date "2002-01-01" @default.
- W41234546 modified "2023-09-27" @default.
- W41234546 title "THE USE OF HYALURONAN IN TOPICAL DRUG DELIVERY" @default.
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- W41234546 doi "https://doi.org/10.1533/9781845693121.247" @default.
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