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- W41328677 abstract "In the current study, we assessed damage induced in the triceps surae muscles after 2,3 or 4 hours of tourniquet (TK) application followed by 7 to 42 days of recovery. Peak tetanic tension was measured, and the triceps surae group of the TK and untreated contralateral legs were analyzed histologically. The percent of muscle area occupied by viable muscle fibers and the average myofiber size in square micrometers were determined. Peak tetanic tension (Po) dropped to 27% of contralateral values 14 days after 3 hours TK, but increased to 56% after 28 days. Po in the 4 hour TK group ranged from 26% to 65% of contralateral Po between 21 and 42 days post-TK, respectively. A decrease in muscle weights correlated with the reduction in contractile force (R2=0.41). After 2 to 4 hours of TK application and 7 days recovery, percent occupancy in the Plantaris muscle ranged from 71.6±6.4 to 43.0±3.5, respectively, while in the Soleus muscle percent occupancy ranged from 85.0±2.3, to 39.9±5.0. Average cell size in Plantaris muscle ranged from 2780±290 to 418±80 μm2 after 2 to 4 hours of TK application and 7 days recovery, while average cell size in Soleus muscle ranged from 3240±300 to 269±30 μm2. As duration of recovery increased, percent occupancy and cell size increased in both the Plantaris and Soleus muscles. These findings demonstrate the progressive increase in necrotic damage induced in muscle after TK of 2, 3 or 4 hours and the progressive increase in peak tetanic tension, viable muscle area and cell size with increasing periods of recovery of 7 to 42 days." @default.
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- W41328677 date "2006-03-01" @default.
- W41328677 modified "2023-10-16" @default.
- W41328677 title "Attenuated recovery from ischemia/reperfusion in 4‐hour tourniquet application" @default.
- W41328677 doi "https://doi.org/10.1096/fasebj.20.5.a1158" @default.
- W41328677 hasPublicationYear "2006" @default.
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