FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W41336079> ?p ?o ?g. }

• W41336079 endingPage "1524" @default.
• W41336079 startingPage "1517" @default.
• W41336079 abstract "Abstract Deficiency of functional deoxycytidine kinase (dCK) is a common characteristic for in vitro resistance to cytarabine (AraC). To investigate whether dCK is also a target for induction of AraC resistance in patients with acute myeloid leukemia (AML), we determined dCK messenger RNA (mRNA) expression in (purified) leukemic blasts and phytohemagglutinin-stimulated T cells (PHA T cells) from patients with chemotherapy-sensitive and chemotherapy-resistant AML. In control samples from healthy donors (PHA T cells and bone marrow), only wild-type dCK complementary DNA (cDNA) was amplified. Also, in (purified) leukemic blasts from patients with sensitive AML, only wild-type dCK cDNAs were observed. These cDNAs coded for active dCK proteins in vitro. However, in 7 of 12 (purified) leukemic blast samples from patients with resistant AML, additional polymerase chain reaction fragments with a deletion of exon 5, exons 3 to 4, exons 3 to 6, or exons 2 to 6 were detected in coexpression with wild-type dCK. Deletion of exons 3 to 6 was also identified in 6 of 12 PHA T cells generated from the patients with resistant AML. The deleted dCK mRNAs were formed by alternative splicing and did code for inactive dCK proteins in vitro. These findings suggest that the presence of inactive, alternatively spliced dCK mRNA transcripts in resistant AML blasts may contribute to the process of AraC resistance in patients with AML." @default.
• W41336079 created "2016-06-24" @default.
• W41336079 creator A5000742781 @default.
• W41336079 creator A5043097913 @default.
• W41336079 creator A5055745584 @default.
• W41336079 creator A5078064159 @default.
• W41336079 creator A5081186852 @default.
• W41336079 date "2000-08-15" @default.
• W41336079 modified "2023-10-13" @default.
• W41336079 title "High incidence of alternatively spliced forms of deoxycytidine kinase in patients with resistant acute myeloid leukemia" @default.
• W41336079 cites W111617592 @default.
• W41336079 cites W1501974728 @default.
• W41336079 cites W1533006219 @default.
• W41336079 cites W1609302917 @default.
• W41336079 cites W1966428567 @default.
• W41336079 cites W1972282671 @default.
• W41336079 cites W1995927666 @default.
• W41336079 cites W2009632514 @default.
• W41336079 cites W2012112824 @default.
• W41336079 cites W2021300545 @default.
• W41336079 cites W2029007438 @default.
• W41336079 cites W2029938020 @default.
• W41336079 cites W2032426692 @default.
• W41336079 cites W2032879930 @default.
• W41336079 cites W2044837239 @default.
• W41336079 cites W2056226887 @default.
• W41336079 cites W2061909512 @default.
• W41336079 cites W2062790845 @default.
• W41336079 cites W2077565737 @default.
• W41336079 cites W2078230554 @default.
• W41336079 cites W2080942477 @default.
• W41336079 cites W2082519456 @default.
• W41336079 cites W2090891788 @default.
• W41336079 cites W2091973614 @default.
• W41336079 cites W2136032428 @default.
• W41336079 cites W2333633096 @default.
• W41336079 cites W2335453665 @default.
• W41336079 cites W270568657 @default.
• W41336079 doi "https://doi.org/10.1182/blood.v96.4.1517" @default.
• W41336079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10942400" @default.
• W41336079 hasPublicationYear "2000" @default.
• W41336079 type Work @default.
• W41336079 sameAs 41336079 @default.
• W41336079 citedByCount "73" @default.
• W41336079 countsByYear W413360792012 @default.
• W41336079 countsByYear W413360792013 @default.
• W41336079 countsByYear W413360792014 @default.
• W41336079 countsByYear W413360792015 @default.
• W41336079 countsByYear W413360792017 @default.
• W41336079 countsByYear W413360792018 @default.
• W41336079 countsByYear W413360792019 @default.
• W41336079 countsByYear W413360792020 @default.
• W41336079 countsByYear W413360792021 @default.
• W41336079 countsByYear W413360792023 @default.
• W41336079 crossrefType "journal-article" @default.
• W41336079 hasAuthorship W41336079A5000742781 @default.
• W41336079 hasAuthorship W41336079A5043097913 @default.
• W41336079 hasAuthorship W41336079A5055745584 @default.
• W41336079 hasAuthorship W41336079A5078064159 @default.
• W41336079 hasAuthorship W41336079A5081186852 @default.
• W41336079 hasBestOaLocation W413360791 @default.
• W41336079 hasConcept C104317684 @default.
• W41336079 hasConcept C153911025 @default.
• W41336079 hasConcept C203014093 @default.
• W41336079 hasConcept C2776694085 @default.
• W41336079 hasConcept C2777844706 @default.
• W41336079 hasConcept C2778041864 @default.
• W41336079 hasConcept C2778461978 @default.
• W41336079 hasConcept C2778729363 @default.
• W41336079 hasConcept C2779268695 @default.
• W41336079 hasConcept C2779282312 @default.
• W41336079 hasConcept C2780007613 @default.
• W41336079 hasConcept C2780258809 @default.
• W41336079 hasConcept C36823959 @default.
• W41336079 hasConcept C502942594 @default.
• W41336079 hasConcept C54355233 @default.
• W41336079 hasConcept C86803240 @default.
• W41336079 hasConceptScore W41336079C104317684 @default.
• W41336079 hasConceptScore W41336079C153911025 @default.
• W41336079 hasConceptScore W41336079C203014093 @default.
• W41336079 hasConceptScore W41336079C2776694085 @default.
• W41336079 hasConceptScore W41336079C2777844706 @default.
• W41336079 hasConceptScore W41336079C2778041864 @default.
• W41336079 hasConceptScore W41336079C2778461978 @default.
• W41336079 hasConceptScore W41336079C2778729363 @default.
• W41336079 hasConceptScore W41336079C2779268695 @default.
• W41336079 hasConceptScore W41336079C2779282312 @default.
• W41336079 hasConceptScore W41336079C2780007613 @default.
• W41336079 hasConceptScore W41336079C2780258809 @default.
• W41336079 hasConceptScore W41336079C36823959 @default.
• W41336079 hasConceptScore W41336079C502942594 @default.
• W41336079 hasConceptScore W41336079C54355233 @default.
• W41336079 hasConceptScore W41336079C86803240 @default.
• W41336079 hasIssue "4" @default.
• W41336079 hasLocation W413360791 @default.
• W41336079 hasOpenAccess W41336079 @default.
• W41336079 hasPrimaryLocation W413360791 @default.
• W41336079 hasRelatedWork W1505669602 @default.

• next