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• W413987329 abstract "There are a variety of neurochemical and morphological changes that occur in the striatum as a consequence of lesioning of the mesostriatal dopamine (DA) system. These changes reflect both the acute loss of DA innervation and compensations for that loss. Acute changes include the loss of tyrosine hydroxylase (TH) immunoreactive fibers and terminals, the appearance of axonal and terminal degeneration, loss of striatal DA content and an increase in the expression of preproenkephalin (PPE) mRNA.1,20 Compensatory responses include increased synthesis of TH, increased DA release and turnover, and decreased DA uptake, leading to maintenance of normal or near normal levels of extracellular dopamine24,31,32.KeywordsTyrosine HydroxylaseVentral StriatumMPTP TreatmentImmunoreactive FiberOpen ArrowheadThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
• W413987329 created "2016-06-24" @default.
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• W413987329 date "2002-01-01" @default.
• W413987329 modified "2023-09-27" @default.
• W413987329 title "Responses to Partial Dopaminergic Lesion: Evidence for Compensatory Sprouting from the Ventral Striatum" @default.
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• W413987329 doi "https://doi.org/10.1007/978-1-4615-0715-4_32" @default.
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