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- W41399734 abstract "The role of the sympathetic nervous system in cardiac, renal and peripheral vascular adrenoceptor-mediated responses was investigated in patients with essential hypertension and age-matched normotensive subjects. Regardless of age, plasma adrenaline was significantly higher in hypertensive when compared with normotensive subjects. This suggests a sympatho-adrenal factor in essential hypertension. Plasma noradrenaline tended to increase with age but its similarity between normotensive and hypertensive subjects points to similar postganglionic neural activity and/or similar overflow of noradrenaline into the circulation. On the other hand, beta-adrenoceptor-mediated tachycardia in response to exercise and intravenous isoproterenol as well as the forearm vasodilator response to intraarterial isoproterenol decreased in normal subjects with older age. In hypertensives this age-dependent beta-receptor-related effect tends to be enhanced as judged from the greater reduction of cardiac isoproterenol sensitivity and the blunted renin response to exercise stimulation." @default.
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- W41399734 date "1980-01-01" @default.
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- W41399734 title "Blunting of Beta-Adrenoceptor-Mediated Cardiovascular Responses and Increasing Alpha-Receptor-Mediated Vasoconstriction: An Age-Dependent Transformation of Essential Hypertension" @default.
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- W41399734 doi "https://doi.org/10.1007/978-3-642-67712-0_5" @default.
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