Matches in SemOpenAlex for { <https://semopenalex.org/work/W414239325> ?p ?o ?g. }
- W414239325 endingPage "e1005256" @default.
- W414239325 startingPage "e1005256" @default.
- W414239325 abstract "The Vibrio cholerae bacterium is the agent of cholera. The capacity to produce the cholera toxin, which is responsible for the deadly diarrhea associated with cholera epidemics, is encoded in the genome of a filamentous phage, CTXφ. Rolling-circle replication (RCR) is central to the life cycle of CTXφ because amplification of the phage genome permits its efficient integration into the genome and its packaging into new viral particles. A single phage-encoded HUH endonuclease initiates RCR of the proto-typical filamentous phages of enterobacteriaceae by introducing a nick at a specific position of the double stranded DNA form of the phage genome. The rest of the process is driven by host factors that are either essential or crucial for the replication of the host genome, such as the Rep SF1 helicase. In contrast, we show here that the histone-like HU protein of V. cholerae is necessary for the introduction of a nick by the HUH endonuclease of CTXφ. We further show that CTXφ RCR depends on a SF1 helicase normally implicated in DNA repair, UvrD, rather than Rep. In addition to CTXφ, we show that VGJφ, a representative member of a second family of vibrio integrative filamentous phages, requires UvrD and HU for RCR while TLCφ, a satellite phage, depends on Rep and is independent from HU." @default.
- W414239325 created "2016-06-24" @default.
- W414239325 creator A5013647603 @default.
- W414239325 creator A5059534120 @default.
- W414239325 creator A5071390616 @default.
- W414239325 date "2015-05-20" @default.
- W414239325 modified "2023-10-18" @default.
- W414239325 title "CTXφ Replication Depends on the Histone-Like HU Protein and the UvrD Helicase" @default.
- W414239325 cites W1481455535 @default.
- W414239325 cites W1498020501 @default.
- W414239325 cites W1516002069 @default.
- W414239325 cites W1545144069 @default.
- W414239325 cites W1584887355 @default.
- W414239325 cites W1678434774 @default.
- W414239325 cites W1754072307 @default.
- W414239325 cites W1894909642 @default.
- W414239325 cites W1921590986 @default.
- W414239325 cites W1963976589 @default.
- W414239325 cites W1969155303 @default.
- W414239325 cites W1972267834 @default.
- W414239325 cites W1974231532 @default.
- W414239325 cites W1975716692 @default.
- W414239325 cites W1977062683 @default.
- W414239325 cites W1977151336 @default.
- W414239325 cites W1982519372 @default.
- W414239325 cites W1984445465 @default.
- W414239325 cites W1987860660 @default.
- W414239325 cites W1988708705 @default.
- W414239325 cites W1991548363 @default.
- W414239325 cites W1994158536 @default.
- W414239325 cites W1994621541 @default.
- W414239325 cites W1995123829 @default.
- W414239325 cites W1997337736 @default.
- W414239325 cites W1999325571 @default.
- W414239325 cites W1999534610 @default.
- W414239325 cites W2001304636 @default.
- W414239325 cites W2003794627 @default.
- W414239325 cites W2003841579 @default.
- W414239325 cites W2010004073 @default.
- W414239325 cites W2013771205 @default.
- W414239325 cites W2025039888 @default.
- W414239325 cites W2027573386 @default.
- W414239325 cites W2030444324 @default.
- W414239325 cites W2031523511 @default.
- W414239325 cites W2033213046 @default.
- W414239325 cites W2043185397 @default.
- W414239325 cites W2043274368 @default.
- W414239325 cites W2044477331 @default.
- W414239325 cites W2052558548 @default.
- W414239325 cites W2053344774 @default.
- W414239325 cites W2066452573 @default.
- W414239325 cites W2067477145 @default.
- W414239325 cites W2073585397 @default.
- W414239325 cites W2084235692 @default.
- W414239325 cites W2084874442 @default.
- W414239325 cites W2085313669 @default.
- W414239325 cites W2089013942 @default.
- W414239325 cites W2092673033 @default.
- W414239325 cites W2093181144 @default.
- W414239325 cites W2095729768 @default.
- W414239325 cites W2096804554 @default.
- W414239325 cites W2101213180 @default.
- W414239325 cites W2104387858 @default.
- W414239325 cites W2104509150 @default.
- W414239325 cites W2105907677 @default.
- W414239325 cites W2111720120 @default.
- W414239325 cites W2112331024 @default.
- W414239325 cites W2113126820 @default.
- W414239325 cites W2119652586 @default.
- W414239325 cites W2126259583 @default.
- W414239325 cites W2126550926 @default.
- W414239325 cites W2135015314 @default.
- W414239325 cites W2135580745 @default.
- W414239325 cites W2138000083 @default.
- W414239325 cites W2141359198 @default.
- W414239325 cites W2150010294 @default.
- W414239325 cites W2150905099 @default.
- W414239325 cites W2151070144 @default.
- W414239325 cites W2151687803 @default.
- W414239325 cites W2152234140 @default.
- W414239325 cites W2159704485 @default.
- W414239325 cites W2163827697 @default.
- W414239325 cites W2164263567 @default.
- W414239325 cites W2164857213 @default.
- W414239325 cites W2406040091 @default.
- W414239325 cites W2416004384 @default.
- W414239325 cites W2784832113 @default.
- W414239325 cites W2883392862 @default.
- W414239325 cites W4211185542 @default.
- W414239325 cites W4211207408 @default.
- W414239325 cites W4236585064 @default.
- W414239325 cites W888995547 @default.
- W414239325 doi "https://doi.org/10.1371/journal.pgen.1005256" @default.
- W414239325 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4439123" @default.
- W414239325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25992634" @default.
- W414239325 hasPublicationYear "2015" @default.
- W414239325 type Work @default.
- W414239325 sameAs 414239325 @default.