Matches in SemOpenAlex for { <https://semopenalex.org/work/W414544039> ?p ?o ?g. }
- W414544039 abstract "Numerous proteins, many essential for the DNA replication machinery, interact with proliferating cell nuclear antigen (PCNA) through the PCNA-interacting peptide (PIP) sequence called the PIP box. We have previously shown that the oxidative demethylase human AlkB homologue 2 (hABH2) colocalizes with PCNA in replication foci. In this study, we show that hABH2 interacts with a posttranslationally modified PCNA via a novel PCNA-interacting motif, which we term AlkB homologue 2 PCNA-interacting motif (APIM). We identify APIM in >200 other proteins involved in DNA maintenance, transcription, and cell cycle regulation, and verify a functional APIM in five of these. Expression of an APIM peptide increases the cellular sensitivity to several cytostatic agents not accounted for by perturbing only the hABH2-PCNA interaction. Thus, APIM is likely to mediate PCNA binding in many proteins involved in DNA repair and cell cycle control during genotoxic stress." @default.
- W414544039 created "2016-06-24" @default.
- W414544039 creator A5046404128 @default.
- W414544039 date "2010-01-01" @default.
- W414544039 modified "2023-09-26" @default.
- W414544039 title "DNA repair protein complexes, functionality and significance for repair efficiency and cell survival" @default.
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