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- W414620002 abstract "Background • AChE is a serine protease that breaks down the neurotransmitter acetylcholine to terminate neurotransmission. • AChE is present in all nerve synapses, neuromuscular junctions, and RBCs. • OPs are commonly found oil additives, pesticides, and chemical weapons, which can target and inhibit AChE. • Acute cholinergic crisis, is the major manifestation of OP poisoning. Inhibition of synaptic AChE causes an accumulation of acetylcholine in the nerve synapse leading to continuous neurotransmission and possible death within minutes. • Molecular Dynamic (MD) analysis was performed to elucidate characteristics of enzyme/adduct to aid design of more effective countermeasures of OP poisoning." @default.
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- W414620002 date "2012-01-01" @default.
- W414620002 modified "2023-09-27" @default.
- W414620002 title "Informing Drug Design: Human Acetylcholinesterase Response to Organophosphate Poisoning" @default.
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