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- W41481238 abstract "MK-801 infused bilaterally into the nucleus accumbens of rats produced a dose-related increase in locomotor activity that was not blocked by intra-accumbers infusion of haloperidol (2.5 μg). Intra-accumbens infusion of L-glutamate (1.0 μg) was without effect when administered alone, but significantly enhanced the increase in locomotor activity produced by MK-801 (5.0 μm). The inactive isomer of MK-801 did not produce hypermotility and L-glutamate did not enhance amphetamine (intra-accumbens)-induced hypermotility. These results extend to an in vivo model electrophysiological and radioligand binding studies demonstrating an enhancement of MK-801 activity by L-glutamate. The results also reinforce the concept that such an enhancement would occur during an escalation of excitatory amino acid levels accompanying pathological overload and, thus, would trigger a compensatory neuronal protection by MK-801." @default.
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- W41481238 date "1989-01-01" @default.
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- W41481238 title "demonstration of the enhancement of MK-801 by L-glutamate" @default.
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- W41481238 doi "https://doi.org/10.1016/0024-3205(89)90454-2" @default.
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