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- W415455488 startingPage "697" @default.
- W415455488 abstract "Ethanol (EtOH) is the most ancient drug and one of those most used and abused by human beings. Although its effects are better known and are best studied on the cytoskeleton of hepatocytes (due to the EtOH role in the etiology of liver cirrhosis), its effects on nerve tissue cells’ cytoskeleton are beginning to be elucidated. We review in this chapter the known mechanisms by which EtOH affects microtubules, intermediate filaments, and microfilaments. EtOH disrupts the cytoskeleton in many different and still incompletely known ways (spontaneous chemical reactions with derivatives of EtOH metabolism, changes in the expression level of cytoskeletal proteins, functional modification of proteins with regulatory actions on cytoskeleton assembly or disassembly, etc.). EtOH’s deleterious effects, by acting on neuronal and glial cytoskeleton during embryonic and/or fetal development, are a critical factor in the induction of alcohol-related neurodevelopmental disorders (ARND) and fetal alcohol syndrome (FAS). Its cytoskeletal actions during adulthood are also critical in the induction of different neuropsychiatric disorders (such as alcoholic dementia). However, existing evidence points to the fact that EtOH disruption of cytoskeleton in neurons is shared with the effects of other noxious stimuli (hypoxia-asphyxia, traumatic brain injuries, electrical discharges, neurotoxicants, other drugs of abuse, neurodegenerative disorders, etc.). We propose here that a presently forgotten and disregarded (but classically described) form of chronic neuronal disease (Zellschrumpfung) is an ancient morphological evidence of neuronal cytoskeletal involvement in the action of those many noxious stimuli. Taking into account all the existing present and historical evidence, we may conclude that the damage to the cytoskeleton is a common final pathway for neuronal damage." @default.
- W415455488 created "2016-06-24" @default.
- W415455488 creator A5057886797 @default.
- W415455488 creator A5085595368 @default.
- W415455488 date "2010-12-02" @default.
- W415455488 modified "2023-10-14" @default.
- W415455488 title "Ethanol Effects on the Cytoskeleton of Nerve Tissue Cells" @default.
- W415455488 cites W1511484676 @default.
- W415455488 cites W1520603144 @default.
- W415455488 cites W1604673910 @default.
- W415455488 cites W1604718336 @default.
- W415455488 cites W1636889788 @default.
- W415455488 cites W1684656424 @default.
- W415455488 cites W1875259453 @default.
- W415455488 cites W1964650815 @default.
- W415455488 cites W1965069238 @default.
- W415455488 cites W1965420960 @default.
- W415455488 cites W1966112595 @default.
- W415455488 cites W1967420575 @default.
- W415455488 cites W1967976287 @default.
- W415455488 cites W1970300404 @default.
- W415455488 cites W1970497135 @default.
- W415455488 cites W1970977249 @default.
- W415455488 cites W1971755318 @default.
- W415455488 cites W1972421000 @default.
- W415455488 cites W1973303770 @default.
- W415455488 cites W1973561604 @default.
- W415455488 cites W1973984152 @default.
- W415455488 cites W1975216375 @default.
- W415455488 cites W1976031430 @default.
- W415455488 cites W1977493316 @default.
- W415455488 cites W1979682928 @default.
- W415455488 cites W1979832500 @default.
- W415455488 cites W1981549228 @default.
- W415455488 cites W1982047567 @default.
- W415455488 cites W1984331201 @default.
- W415455488 cites W1984354039 @default.
- W415455488 cites W1984732054 @default.
- W415455488 cites W1991909451 @default.
- W415455488 cites W1993220836 @default.
- W415455488 cites W1994214389 @default.
- W415455488 cites W1995237824 @default.
- W415455488 cites W1995559857 @default.
- W415455488 cites W1997509439 @default.
- W415455488 cites W2000022451 @default.
- W415455488 cites W2001906057 @default.
- W415455488 cites W2002289637 @default.
- W415455488 cites W2005737344 @default.
- W415455488 cites W2005746771 @default.
- W415455488 cites W2005984783 @default.
- W415455488 cites W2007399590 @default.
- W415455488 cites W2008094802 @default.
- W415455488 cites W2012136237 @default.
- W415455488 cites W2012200185 @default.
- W415455488 cites W2018509322 @default.
- W415455488 cites W2018613448 @default.
- W415455488 cites W2019402991 @default.
- W415455488 cites W2022113999 @default.
- W415455488 cites W2023008248 @default.
- W415455488 cites W2025412939 @default.
- W415455488 cites W2030338901 @default.
- W415455488 cites W2033241989 @default.
- W415455488 cites W2037413425 @default.
- W415455488 cites W2037558767 @default.
- W415455488 cites W2038893880 @default.
- W415455488 cites W2040340635 @default.
- W415455488 cites W2040680390 @default.
- W415455488 cites W2041105109 @default.
- W415455488 cites W2041486804 @default.
- W415455488 cites W2041718901 @default.
- W415455488 cites W2042310284 @default.
- W415455488 cites W2042739359 @default.
- W415455488 cites W2043879728 @default.
- W415455488 cites W2044963651 @default.
- W415455488 cites W2046746554 @default.
- W415455488 cites W2049842274 @default.
- W415455488 cites W2050378500 @default.
- W415455488 cites W2051221143 @default.
- W415455488 cites W2052105313 @default.
- W415455488 cites W2052362668 @default.
- W415455488 cites W2053173515 @default.
- W415455488 cites W2053894204 @default.
- W415455488 cites W2054674240 @default.
- W415455488 cites W2054844454 @default.
- W415455488 cites W2055168608 @default.
- W415455488 cites W2055913792 @default.
- W415455488 cites W2056305108 @default.
- W415455488 cites W2057483650 @default.
- W415455488 cites W2060860482 @default.
- W415455488 cites W2062212900 @default.
- W415455488 cites W2062470404 @default.
- W415455488 cites W2062859104 @default.
- W415455488 cites W2063511140 @default.
- W415455488 cites W2063586313 @default.
- W415455488 cites W2064768618 @default.
- W415455488 cites W2064959533 @default.
- W415455488 cites W2065140692 @default.
- W415455488 cites W2066531385 @default.