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- W41547570 abstract "The possible roles of the mitogen-activated protein kinases (MAPKs) ERK-1 and ERK-2 in mediating growth-promoting and hypertrophic responses were investigated by examining the effect of H2O2 on ERK-1 and ERK-2 phosphorylation and activation in an established vascular smooth muscle cell (VSMC) line (A10). H2O2 treatment of VSMCs stimulated the phosphorylation of both ERK-1 and ERK-2 in a concentration-dependent manner with maximal impact at the dose level of 2mM H2O2. Treatment of cells with aminotriazole, an inhibitor of catalase, potentiated the effect of H2O2 and reduced the H2O2 concentration required to elicit the maximum response. In addition, PD98059, an inhibitor of MAPK kinase (MEK), and wortmannin, an inhibitor of phosphatidylinositol 3-kinase (PI3K), attenuated the H2O2-induced activation of ERK-1 and ERK-2. H2O2 was also found to stimulate PI3K activity, which was inhibited by wortmannin. Taken together, these data demonstrate that oxidative stress-induced ERK activation is mediated, at least in part, through a PI3K-dependent pathway and suggest a role of this pathway in eliciting growth-promoting and hypertrophic responses to H2O2 in VSMCs." @default.
- W41547570 created "2016-06-24" @default.
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- W41547570 date "2000-01-01" @default.
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- W41547570 title "Stimulation of Mitogen-Activated Protein Kinases ERK-1 and ERK-2 by H2O2 in Vascular Smooth Muscle Cells" @default.
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