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- W41608258 abstract "It was the aim of this study to elucidate in which manner active metabolites of tobacco specific nitrosamines are distributed systemically. The experimental approach was to assess genotoxic effects by 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N-nitrosonornicotine (NNN). For this, induced DNA single strand breaks (SSB) were determined by two different methods in isolated cells of different organs following single p.o. application and 1 h exposure to the test chemicals. So far, with the alkaline elution technique it was found that NNK induces SSB beginning at 25 mg/kg in the liver. NNN was not genotoxic in the liver up to 100 mg /kg, and the compound was only moderately positive in doses up to 500 mg/kg. No genotoxicity was observed in testes, or thymus by either compound. First results with a single cell analysis of DNA damage by in situ nick translation indicate both the compounds to be genotoxic in esophageal cells." @default.
- W41608258 created "2016-06-24" @default.
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- W41608258 date "1991-01-01" @default.
- W41608258 modified "2023-09-26" @default.
- W41608258 title "Toxicokinetics of Nicotine-Derived Nitrosamines in the Rat" @default.
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- W41608258 doi "https://doi.org/10.1007/978-3-0348-7457-1_16" @default.
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