Matches in SemOpenAlex for { <https://semopenalex.org/work/W41666894> ?p ?o ?g. }
- W41666894 abstract "Alzheimer's disease (AD) is the gradual loss of the cognitive function due to neuronal death. Currently no therapy is available to slow down, reverse or prevent the disease. Here we analyze the existing data in literature and hypothesize that the physiological function of the Amyloid Precursor Protein (APP) is activating the AppBp1 pathway and this function is gradually lost during the progression of AD pathogenesis. The AppBp1 pathway, also known as the neddylation pathway, activates the small ubiquitin-like protein nedd8, which covalently modifies and switches on Cullin ubiquitin ligases, which are essential in the turnover of cell cycle proteins. Here we discuss how APP may activate the AppBp1 pathway, which downregulates cell cycle markers and protects genome integrity. More investigation of this mechanism-driven hypothesis may provide insights into disease treatment and prevention strategies." @default.
- W41666894 created "2016-06-24" @default.
- W41666894 creator A5011373418 @default.
- W41666894 creator A5055047732 @default.
- W41666894 creator A5060564482 @default.
- W41666894 creator A5061381608 @default.
- W41666894 creator A5064140857 @default.
- W41666894 creator A5076260076 @default.
- W41666894 date "2014-01-01" @default.
- W41666894 modified "2023-09-23" @default.
- W41666894 title "Cycle on Wheels: Is APP Key to the AppBp1 Pathway?" @default.
- W41666894 cites W1485747833 @default.
- W41666894 cites W1550100123 @default.
- W41666894 cites W1580332068 @default.
- W41666894 cites W1588478093 @default.
- W41666894 cites W1595531455 @default.
- W41666894 cites W1644122431 @default.
- W41666894 cites W1822725522 @default.
- W41666894 cites W1851952707 @default.
- W41666894 cites W1935951477 @default.
- W41666894 cites W1964213184 @default.
- W41666894 cites W1964492562 @default.
- W41666894 cites W1965055049 @default.
- W41666894 cites W1966980496 @default.
- W41666894 cites W1968297558 @default.
- W41666894 cites W1969209100 @default.
- W41666894 cites W1969271586 @default.
- W41666894 cites W1969412746 @default.
- W41666894 cites W1969418378 @default.
- W41666894 cites W1974846270 @default.
- W41666894 cites W1975228929 @default.
- W41666894 cites W1975670052 @default.
- W41666894 cites W1977496522 @default.
- W41666894 cites W1979987334 @default.
- W41666894 cites W1980462590 @default.
- W41666894 cites W1982855701 @default.
- W41666894 cites W1986682972 @default.
- W41666894 cites W1986810511 @default.
- W41666894 cites W1989674704 @default.
- W41666894 cites W1991194956 @default.
- W41666894 cites W1991841644 @default.
- W41666894 cites W1995925086 @default.
- W41666894 cites W2006598022 @default.
- W41666894 cites W2007598576 @default.
- W41666894 cites W2011677622 @default.
- W41666894 cites W2014069479 @default.
- W41666894 cites W2016147336 @default.
- W41666894 cites W2022274052 @default.
- W41666894 cites W2022348989 @default.
- W41666894 cites W2024466111 @default.
- W41666894 cites W2025695179 @default.
- W41666894 cites W2027397361 @default.
- W41666894 cites W2029620430 @default.
- W41666894 cites W2030182984 @default.
- W41666894 cites W2030191254 @default.
- W41666894 cites W2034626290 @default.
- W41666894 cites W2034792033 @default.
- W41666894 cites W2034876143 @default.
- W41666894 cites W2038012168 @default.
- W41666894 cites W2041622179 @default.
- W41666894 cites W2044883494 @default.
- W41666894 cites W2045063195 @default.
- W41666894 cites W2046435660 @default.
- W41666894 cites W2047553063 @default.
- W41666894 cites W2049437111 @default.
- W41666894 cites W2056046302 @default.
- W41666894 cites W2056079743 @default.
- W41666894 cites W2056790763 @default.
- W41666894 cites W2057709960 @default.
- W41666894 cites W2058928585 @default.
- W41666894 cites W2060853377 @default.
- W41666894 cites W2061024988 @default.
- W41666894 cites W2068476682 @default.
- W41666894 cites W2068784898 @default.
- W41666894 cites W2073996456 @default.
- W41666894 cites W2074113171 @default.
- W41666894 cites W2076194625 @default.
- W41666894 cites W2080284013 @default.
- W41666894 cites W2081881251 @default.
- W41666894 cites W2082040415 @default.
- W41666894 cites W2082314202 @default.
- W41666894 cites W2084535507 @default.
- W41666894 cites W2086851301 @default.
- W41666894 cites W2088881960 @default.
- W41666894 cites W2089894184 @default.
- W41666894 cites W2090560595 @default.
- W41666894 cites W2091027054 @default.
- W41666894 cites W2091149521 @default.
- W41666894 cites W2091475538 @default.
- W41666894 cites W2091505182 @default.
- W41666894 cites W2092265639 @default.
- W41666894 cites W2093022929 @default.
- W41666894 cites W2100835617 @default.
- W41666894 cites W2102628825 @default.
- W41666894 cites W2104132043 @default.
- W41666894 cites W2104538866 @default.
- W41666894 cites W2105382611 @default.
- W41666894 cites W2108263233 @default.
- W41666894 cites W2108654668 @default.
- W41666894 cites W2109193231 @default.