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- W41680557 abstract "In chickens, the activity of lysine ketoglutarate reductase (LKR) is reported to be proportional to dietary lysine (Wang et al, 1973). LKR activity resides on the bifunctional aminoadipate semialdehyde synthase enzyme (AASS). To investigate regulation of lysine catabolism, chickens (2wk old) were individually caged and fed either a 1.18% (adequate lysine, N=8) or 0.73% (low lysine, N=8) lysine diet. After 8 days, livers were removed and a portion of each liver was quick frozen in liquid nitrogen to evaluate mRNA expression, and the remaining portion was used for protein assays. Hepatic LKR activity was measured spectrophotometrically at 340nm. AASS and lysyl oxidase (an alternative route of lysine catabolism-LOX) mRNA expression were measured by real-time PCR. AASS protein abundance was measured by western blotting. Surprisingly, chickens fed a low lysine diet gained more weight (P<0.05) than chickens fed the lysine adequate diet, 157.6±13.7 and 113.1±13.7 g respectively. Chickens fed the low lysine diet had a smaller (P<0.05) relative liver size then chickens fed the lysine adequate diet, 3.16±0.23 and 4.23±0.23%, respectively. No significant differences in liver weight, feed consumption, feed efficiency, LKR activity, AASS protein abundance, AASS or LOX mRNA were detected. The results of this study show that 1) chickens can be resistant to short term deficiencies of dietary lysine and 2) alterations in lysine catabolism could be mediated by pathways other then those depending on LOX or AASS. Support: WV Ag. For. Expt. Sta., WVU Res. Corp. and the USDA NRI-2004-35206-14160 (KPB)." @default.
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- W41680557 date "2006-03-01" @default.
- W41680557 modified "2023-09-27" @default.
- W41680557 title "Lysine catabolism in chickens fed at or below their lysine requirement" @default.
- W41680557 doi "https://doi.org/10.1096/fasebj.20.5.a1042-b" @default.
- W41680557 hasPublicationYear "2006" @default.
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