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• W41702537 abstract "Senile dementia of the Alzheimer’s type (SDAT) is a slowly progressive neurological disorder which is characterized by severe and debilitating memory loss. This insidious and pernicious malady is expected to strike 20% of all individuals over the age of eighty (Bartus et al., 1982), an important and growing demographic block. At present the etiological basis of SDAT is unknown and work has been aimed at palliative treatments to increase the quality of life of those individuals stricken with the disease. In SDAT, numerous biochemical/physiological observations have suggested that a cholinergic deficit is in some way related to the disease (Becker and Giacobini, 1988 and references cited therein). Such evidence includes selective degeneration of cholinergic neurons in the basal forebrain, decreased activity and concentration of acetyl choline (ACh), choline acetyltransferase, the enzyme responsible for synthesizing ACh and acetyl cholinesterase (AChE), the enzyme responsible for ACh degradation (Sims et al., 1983). Given this biochemical basis for dementia, therapeutic approach have concentrated on bolstering the impaired cholinergic system either by agonist administration (Corkin, 1981) or by developments of AChE inhibitors. Compounds resulting from the latter scheme have offered the most potential in SDAT and include physostigmine, aminopyridines and 9amino-1,2,3,4-tetrahydroacridine (THA)." @default.
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• W41702537 date "1989-01-01" @default.
• W41702537 modified "2023-10-07" @default.
• W41702537 title "Brain-Enhanced Delivery of Anti-Dementia Drugs" @default.
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• W41702537 doi "https://doi.org/10.1007/978-1-4684-5727-8_16" @default.
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