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- W417239600 abstract "Bromocriptine mesylate, a semisynthetic ergot alkaloid derivative,is a new tool in the therapy of type 2 diabetes mellitus.The pharmacological activity of bromocriptine occursmainly through activation of D2 receptors and inhibition ofD1 receptors in the CNS. Rapid-release formulation of bromocriptine is used to provide morning dopamine agonism,mimicking the circadian dopamine activity in central nervoussystem observed in non-diabetic subjects. Bromocriptinepossess several properties that are beneficial to diabeticpatients. The drug not only improves glucose metabolism,but also diminishes the risk of the occurrence of seriouscardiovascular complications. It was the first antidiabeticdrug approved under the FDA’s guidelines requiring clinicaltrials to demonstrate cardiovascular safety. Additionally, rapidrelease bromocriptine demonstrates good safety and tolerabilityprofile, and in most instances, the observed adverseevents are not serious and resolve spontaneously over time.Bromocriptine is a promising agent, however its role in thetherapy of type 2 diabetes mellitus is still to be established. Diabet Do¶w Klin 2011; 11, 2: 64–68" @default.
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- W417239600 date "2011-12-20" @default.
- W417239600 modified "2023-09-27" @default.
- W417239600 title "The clinical pharmacology of rapid-release formulation of bromocriptine — a new antidiabetic drug" @default.
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