Matches in SemOpenAlex for { <https://semopenalex.org/work/W4177524> ?p ?o ?g. }
- W4177524 endingPage "7" @default.
- W4177524 startingPage "2062" @default.
- W4177524 abstract "To examine the effect of two retinoids, all-trans-retinoic acid (tretinoin) and all-trans-9-(4-methoxy-2,3,6- trimethylphenyl)-3,7-dimethyl- 2,4,6,8-nonatetraenoic acid (acitretin) on the production of plasminogen activators and plasminogen activator inhibitors by human retinal pigment epithelial cells in culture.Cultures of human retinal pigment epithelial cells were incubated with either of the retinoids at a concentration of 1 microM for 24-72 hours. The media were assayed using solid-phase immunocapture assays and zymography.Both retinoids caused a twofold to sevenfold increase in urokinase-type plasminogen activator in the medium. The effect was seen after 24 hours in culture and was further augmented up to 72 hours. No significant amounts of tissue-type plasminogen activator were detected. The plasminogen activator inhibitor activity was unaffected by the retinoids. Proliferation and morphology of retinal pigment epithelial cells were also unaffected by the retinoids in incubations for up to 72 hours.Retinoids profoundly affect the extracellular proteolysis of retinal pigment epithelial cells in culture. This effect may be related to the differentiation-inducing activity of retinoids seen in other cell types, often connected with changes in extracellular proteolysis. It is possible that retinoids may modulate dedifferentiation, proliferation, and migration of retinal pigment epithelial cells seen in vitro, as well as in the pathogenesis of retinal disease." @default.
- W4177524 created "2016-06-24" @default.
- W4177524 creator A5024623241 @default.
- W4177524 creator A5038914590 @default.
- W4177524 creator A5056645051 @default.
- W4177524 creator A5091180082 @default.
- W4177524 creator A5015607592 @default.
- W4177524 date "1993-05-01" @default.
- W4177524 modified "2023-09-23" @default.
- W4177524 title "Retinoids increase urokinase-type plasminogen activator production by human retinal pigment epithelial cells in culture." @default.
- W4177524 cites W1587951978 @default.
- W4177524 cites W1618760884 @default.
- W4177524 cites W1966323217 @default.
- W4177524 cites W1975256743 @default.
- W4177524 cites W1975939418 @default.
- W4177524 cites W1977178235 @default.
- W4177524 cites W1977659044 @default.
- W4177524 cites W1996636157 @default.
- W4177524 cites W2010468619 @default.
- W4177524 cites W2014112306 @default.
- W4177524 cites W2018650295 @default.
- W4177524 cites W2020725836 @default.
- W4177524 cites W2032588194 @default.
- W4177524 cites W2033269379 @default.
- W4177524 cites W2046402705 @default.
- W4177524 cites W2047309494 @default.
- W4177524 cites W2049107755 @default.
- W4177524 cites W2078700641 @default.
- W4177524 cites W2100837269 @default.
- W4177524 cites W2112990955 @default.
- W4177524 cites W2234386852 @default.
- W4177524 cites W2268283475 @default.
- W4177524 cites W23122061 @default.
- W4177524 cites W2339481704 @default.
- W4177524 cites W2397575495 @default.
- W4177524 cites W2418189265 @default.
- W4177524 cites W38263071 @default.
- W4177524 cites W91805030 @default.
- W4177524 cites W17299339 @default.
- W4177524 cites W95729161 @default.
- W4177524 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8491555" @default.
- W4177524 hasPublicationYear "1993" @default.
- W4177524 type Work @default.
- W4177524 sameAs 4177524 @default.
- W4177524 citedByCount "4" @default.
- W4177524 crossrefType "journal-article" @default.
- W4177524 hasAuthorship W4177524A5015607592 @default.
- W4177524 hasAuthorship W4177524A5024623241 @default.
- W4177524 hasAuthorship W4177524A5038914590 @default.
- W4177524 hasAuthorship W4177524A5056645051 @default.
- W4177524 hasAuthorship W4177524A5091180082 @default.
- W4177524 hasConcept C109523444 @default.
- W4177524 hasConcept C134018914 @default.
- W4177524 hasConcept C153911025 @default.
- W4177524 hasConcept C177430391 @default.
- W4177524 hasConcept C2776572282 @default.
- W4177524 hasConcept C2776892390 @default.
- W4177524 hasConcept C2778024200 @default.
- W4177524 hasConcept C2779059073 @default.
- W4177524 hasConcept C2779679481 @default.
- W4177524 hasConcept C2780428090 @default.
- W4177524 hasConcept C2780827179 @default.
- W4177524 hasConcept C2781121885 @default.
- W4177524 hasConcept C28406088 @default.
- W4177524 hasConcept C54355233 @default.
- W4177524 hasConcept C55493867 @default.
- W4177524 hasConcept C81885089 @default.
- W4177524 hasConcept C86803240 @default.
- W4177524 hasConceptScore W4177524C109523444 @default.
- W4177524 hasConceptScore W4177524C134018914 @default.
- W4177524 hasConceptScore W4177524C153911025 @default.
- W4177524 hasConceptScore W4177524C177430391 @default.
- W4177524 hasConceptScore W4177524C2776572282 @default.
- W4177524 hasConceptScore W4177524C2776892390 @default.
- W4177524 hasConceptScore W4177524C2778024200 @default.
- W4177524 hasConceptScore W4177524C2779059073 @default.
- W4177524 hasConceptScore W4177524C2779679481 @default.
- W4177524 hasConceptScore W4177524C2780428090 @default.
- W4177524 hasConceptScore W4177524C2780827179 @default.
- W4177524 hasConceptScore W4177524C2781121885 @default.
- W4177524 hasConceptScore W4177524C28406088 @default.
- W4177524 hasConceptScore W4177524C54355233 @default.
- W4177524 hasConceptScore W4177524C55493867 @default.
- W4177524 hasConceptScore W4177524C81885089 @default.
- W4177524 hasConceptScore W4177524C86803240 @default.
- W4177524 hasIssue "6" @default.
- W4177524 hasLocation W41775241 @default.
- W4177524 hasOpenAccess W4177524 @default.
- W4177524 hasPrimaryLocation W41775241 @default.
- W4177524 hasRelatedWork W1977178235 @default.
- W4177524 hasRelatedWork W1982604306 @default.
- W4177524 hasRelatedWork W2007111901 @default.
- W4177524 hasRelatedWork W2030500717 @default.
- W4177524 hasRelatedWork W2035581529 @default.
- W4177524 hasRelatedWork W2037022487 @default.
- W4177524 hasRelatedWork W2093972781 @default.
- W4177524 hasRelatedWork W2149435975 @default.
- W4177524 hasRelatedWork W4177524 @default.