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- W418069681 abstract "Injection/infusion reactions to nanopharmaceuticals (and particulate drug carriers) are idiosyncratic and well documented. The molecular basis of nanoparticle-mediated injection reactions is debatable, with two hypotheses as front-runners. The first is complement-activation-related ‘pseudoallergy’, where a causal role for nanoparticle-mediated complement activation in injection/infusion reactions is considered. However, the second hypothesis (the rapid phagocytic response hypothesis) states a transitional link from robust clearance of nanoparticles (NPs) from the blood by strategically placed responsive macrophages to adverse hemodynamic and cardiopulmonary reactions, regardless of complement activation. Here, I critically examine and discuss these hypotheses. Current experimentally derived evidence appears to be more in support of the rapid phagocytic response hypothesis than of the ‘pseudoallergy’ hypothesis." @default.
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- W418069681 date "2015-08-01" @default.
- W418069681 modified "2023-10-13" @default.
- W418069681 title "Anaphylactic reaction and cardiac arrest due to gadobenate dimeglumine" @default.
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- W418069681 doi "https://doi.org/10.1016/j.accpm.2015.03.006" @default.
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