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- W41809910 abstract "The SHAPES strategy combines nuclear magnetic resonance (NMR) screening of a library of small drug-like molecules with a variety of complementary methods, such as virtual screening, high throughput enzymatic assays, combinatorial chemistry, X-ray crystallography, and molecular modeling, in a directed search for new medicinal chemistry leads. In the past few years, the SHAPES strategy has found widespread utility in pharmaceutical research. To illustrate a variety of different implementations of the method, we will focus in this review on recent applications of the SHAPES strategy in several drug discovery programs at Vertex Pharmaceuticals." @default.
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- W41809910 date "2002-12-01" @default.
- W41809910 modified "2023-09-27" @default.
- W41809910 title "Applications of SHAPES Screening in Drug Discovery" @default.
- W41809910 doi "https://doi.org/10.2174/1386207023329950" @default.
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