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- W41811170 abstract "This review covers aspects of the cardiac mechanotransduction field at different levels, and advocates the possibility that mechanoelectro-chemical transduction forms part of a network of mechanically linked crosstalk in heart – Mechanically Mediated Crosstalk (MMC). It assembles evidence and observations in the literature to promote this hypothesis. Mechanical components can provide the bond between interactions at molecular, cellular, and macro levels to enable the crosstalk. Stretch activated channels exist in heart, but stresses and strains can affect other membrane channels or receptors. A cellular mechanical change can thus promote several ionic or downstream changes. Cell signal cascades have been implicated and, mostly via intracellular Ca, can affect membrane electrophysiology. MMC could shape downstream signals to alter intracellular Ca. MMC also spans other regulatory systems and processes, such as the autonomic nervous system, and in addition, operates through to the whole heart as an integrative system. Finally, supporting the hypothesis, if elements of the normal crosstalk become deranged it contributes to cardiovascular disease and, potentially, lethal arrhythmia." @default.
- W41811170 created "2016-06-24" @default.
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- W41811170 date "2005-01-01" @default.
- W41811170 modified "2023-09-26" @default.
- W41811170 title "Mechanically Mediated Crosstalk in Heart" @default.
- W41811170 hasPublicationYear "2005" @default.
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