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- W418325462 abstract "I~u'po~: To illustrate the multiple causes of hypoxemia to be considered following cardiopulmonary bypass and how therapy given to improve oxygen delivery may have contributed to a decrease in arterial oxygen saturation to life-threatening levels. Cfimc.~! featm'~: A 61 yr old man with severe mitral regurgitation and chronic obstructive lung disease underwent surgery for mitral valve repair. A pulmonary artery catheter with the capacity to measure cardiac output and mixed venous oxygen saturation (SvO2) continuously was used. Two unsuccessful attempts were made to repair the valve which was finally replaced, requiring cardiopulmonary bypass of 317 min. Dobutamine 5 lug'kg -t-rain -I and sodium nitroprusside I/~g'kg -t-rain -I were used to increase cardiac output. Soon after, the SvO 2 decreased progressively from SS to 39%. The patient became cyanotic with a PaO 2 of 39 mmHg. Sodium nitroprusside was stopped and amrinone 100 mg bolus followed by I 0 Alg'kg -I'min -I was given in addition to adding PEEP to the ventilation. With these measures PaO 2 could be maintained at safe levels but PEEP and high inspired oxygen concentrations were needed postoperatively until the trachea could be extubated on the third postoperative day. Conc.JtLsion: The profound hypoxemia in this case was likely due to a combination of intra- and extrapulmonary shunt, both augmented by sodium nitroprusside. The desaturation of mixed venous blood amplified the effect of these shunts in decreasing arterial oxygen saturation. The interaction of these factors are analyzed in this report. Objectis : Illustrer les multiples causes de I'hypoxEmie dont il faut tenir compte apt& une circulation extracorporelle et montrer comment la th&apie qui vise ~ amEliorer la livraison d'oxygEne peut avoir contribuE ~ baisser la saturation art&ielle en oxygEne ~ des niveaux dangereux." @default.
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- W418325462 date "1999-01-01" @default.
- W418325462 modified "2023-09-27" @default.
- W418325462 title "Clinical Reports Profound hypoxemia during treatment of low cardiac output after car- diopulmonary bypass" @default.
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