Matches in SemOpenAlex for { <https://semopenalex.org/work/W419329706> ?p ?o ?g. }
- W419329706 endingPage "e0124058" @default.
- W419329706 startingPage "e0124058" @default.
- W419329706 abstract "Brucella is the causative agent of the zoonotic disease brucellosis, and its success as an intracellular pathogen relies on its ability to adapt to the harsh environmental conditions that it encounters inside the host. The Brucella genome encodes a sensor histidine kinase containing a LOV domain upstream from the kinase, LOVHK, which plays an important role in light-regulated Brucella virulence. In this report we study the intracellular signaling pathway initiated by the light sensor LOVHK using an integrated biochemical and genetic approach. From results of bacterial two-hybrid assays and phosphotransfer experiments we demonstrate that LOVHK functionally interacts with two response regulators: PhyR and LovR, constituting a functional two-component signal-transduction system. LOVHK contributes to the activation of the General Stress Response (GSR) system in Brucella via PhyR, while LovR is proposed to be a phosphate-sink for LOVHK, decreasing its phosphorylation state. We also show that in the absence of LOVHK the expression of the virB operon is down-regulated. In conclusion, our results suggest that LOVHK positively regulates the GSR system in vivo, and has an effect on the expression of the virB operon. The proposed regulatory network suggests a similar role for LOVHK in other microorganisms." @default.
- W419329706 created "2016-06-24" @default.
- W419329706 creator A5000071530 @default.
- W419329706 creator A5022936032 @default.
- W419329706 creator A5030749018 @default.
- W419329706 creator A5031996619 @default.
- W419329706 creator A5057735950 @default.
- W419329706 creator A5075886037 @default.
- W419329706 creator A5089234644 @default.
- W419329706 date "2015-05-19" @default.
- W419329706 modified "2023-10-06" @default.
- W419329706 title "LOV Histidine Kinase Modulates the General Stress Response System and Affects the virB Operon Expression in Brucella abortus" @default.
- W419329706 cites W1535144051 @default.
- W419329706 cites W1556510423 @default.
- W419329706 cites W1580935263 @default.
- W419329706 cites W1964284289 @default.
- W419329706 cites W1968623015 @default.
- W419329706 cites W1970408292 @default.
- W419329706 cites W1974449587 @default.
- W419329706 cites W1980061686 @default.
- W419329706 cites W1984086504 @default.
- W419329706 cites W1984800057 @default.
- W419329706 cites W1993372010 @default.
- W419329706 cites W2003001669 @default.
- W419329706 cites W2004583149 @default.
- W419329706 cites W2006909053 @default.
- W419329706 cites W2006935496 @default.
- W419329706 cites W2009519214 @default.
- W419329706 cites W2016231502 @default.
- W419329706 cites W2025291938 @default.
- W419329706 cites W2027287663 @default.
- W419329706 cites W2029752213 @default.
- W419329706 cites W2034853518 @default.
- W419329706 cites W2036735937 @default.
- W419329706 cites W2040426293 @default.
- W419329706 cites W2043238044 @default.
- W419329706 cites W2047529320 @default.
- W419329706 cites W2050922096 @default.
- W419329706 cites W2053175419 @default.
- W419329706 cites W2055171048 @default.
- W419329706 cites W2056232749 @default.
- W419329706 cites W2058699431 @default.
- W419329706 cites W2059513932 @default.
- W419329706 cites W2062842715 @default.
- W419329706 cites W2076071492 @default.
- W419329706 cites W2082046299 @default.
- W419329706 cites W2092111638 @default.
- W419329706 cites W2093316853 @default.
- W419329706 cites W2093358630 @default.
- W419329706 cites W2093361815 @default.
- W419329706 cites W2098478833 @default.
- W419329706 cites W2101536900 @default.
- W419329706 cites W2106023579 @default.
- W419329706 cites W2106246537 @default.
- W419329706 cites W2106609112 @default.
- W419329706 cites W2107028998 @default.
- W419329706 cites W2110558507 @default.
- W419329706 cites W2112170084 @default.
- W419329706 cites W2112665912 @default.
- W419329706 cites W2113296099 @default.
- W419329706 cites W2113869130 @default.
- W419329706 cites W2117918973 @default.
- W419329706 cites W2119306520 @default.
- W419329706 cites W2125112034 @default.
- W419329706 cites W2127322768 @default.
- W419329706 cites W2131804803 @default.
- W419329706 cites W2132529453 @default.
- W419329706 cites W2138539833 @default.
- W419329706 cites W2147051160 @default.
- W419329706 cites W2147995817 @default.
- W419329706 cites W2152406340 @default.
- W419329706 cites W2153076508 @default.
- W419329706 cites W2166692823 @default.
- W419329706 cites W2168020930 @default.
- W419329706 cites W4211033510 @default.
- W419329706 doi "https://doi.org/10.1371/journal.pone.0124058" @default.
- W419329706 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4438053" @default.
- W419329706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25993430" @default.
- W419329706 hasPublicationYear "2015" @default.
- W419329706 type Work @default.
- W419329706 sameAs 419329706 @default.
- W419329706 citedByCount "25" @default.
- W419329706 countsByYear W4193297062015 @default.
- W419329706 countsByYear W4193297062016 @default.
- W419329706 countsByYear W4193297062017 @default.
- W419329706 countsByYear W4193297062018 @default.
- W419329706 countsByYear W4193297062019 @default.
- W419329706 countsByYear W4193297062020 @default.
- W419329706 countsByYear W4193297062021 @default.
- W419329706 countsByYear W4193297062022 @default.
- W419329706 countsByYear W4193297062023 @default.
- W419329706 crossrefType "journal-article" @default.
- W419329706 hasAuthorship W419329706A5000071530 @default.
- W419329706 hasAuthorship W419329706A5022936032 @default.
- W419329706 hasAuthorship W419329706A5030749018 @default.
- W419329706 hasAuthorship W419329706A5031996619 @default.
- W419329706 hasAuthorship W419329706A5057735950 @default.
- W419329706 hasAuthorship W419329706A5075886037 @default.