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• W419749922 endingPage "449" @default.
• W419749922 startingPage "411" @default.
• W419749922 abstract "Motivational and hedonic impairments are core aspects of a variety of types of psychopathology. These impairments cut across diagnostic categories and may be critical to understanding major aspects of the functional impairments accompanying psychopathology. Given the centrality of motivational and hedonic systems to psychopathology, the Research Domain Criteria (RDoC) initiative includes a positive valence systems domain that outlines a number of constructs that may be key to understanding the nature and mechanisms of motivational and hedonic impairments in psychopathology. These component constructs include initial responsiveness to reward, reward anticipation or expectancy, incentive or reinforcement learning, effort valuation, and action selection. Here, we review behavioral and neuroimaging studies providing evidence for impairments in these constructs in individuals with psychosis versus in individuals with depressive pathology. There are important differences in the nature of reward-related and hedonic deficits associated with psychosis versus depression that have major implications for our understanding of etiology and treatment development. In particular, the literature strongly suggests the presence of impairments in in-the-moment hedonics or liking in individuals with depressive pathology, particularly among those who experience anhedonia. Such deficits may propagate forward and contribute to impairments in other constructs that are dependent on hedonic responses, such as anticipation, learning, effort, and action selection. Such hedonic impairments could reflect alterations in dopamine and/or opioid signaling in the striatum related to depression or specifically to anhedonia in depressed populations. In contrast, the literature points to relatively intact in-the-moment hedonic processing in psychosis, but provides much evidence for impairments in other components involved in translating reward to action selection. Particularly, individuals with schizophrenia exhibit altered reward prediction and associated striatal and prefrontal activation, impaired reward learning, and impaired reward-modulated action selection." @default.
• W419749922 created "2016-06-24" @default.
• W419749922 creator A5033965347 @default.
• W419749922 creator A5048858251 @default.
• W419749922 creator A5070045106 @default.
• W419749922 date "2015-01-01" @default.
• W419749922 modified "2023-09-30" @default.
• W419749922 title "Mechanisms Underlying Motivational Deficits in Psychopathology: Similarities and Differences in Depression and Schizophrenia" @default.
• W419749922 cites W120301641 @default.
• W419749922 cites W1496608909 @default.
• W419749922 cites W1518543521 @default.
• W419749922 cites W1518890501 @default.
• W419749922 cites W1642699591 @default.
• W419749922 cites W1652173018 @default.
• W419749922 cites W1896121363 @default.
• W419749922 cites W1963700723 @default.
• W419749922 cites W1964413986 @default.
• W419749922 cites W1964544901 @default.
• W419749922 cites W1964561629 @default.
• W419749922 cites W1966618733 @default.
• W419749922 cites W1967104219 @default.
• W419749922 cites W1967922673 @default.
• W419749922 cites W1969652836 @default.
• W419749922 cites W1969727558 @default.
• W419749922 cites W1969729492 @default.
• W419749922 cites W1969866816 @default.
• W419749922 cites W1969990561 @default.
• W419749922 cites W1970846977 @default.
• W419749922 cites W1971359675 @default.
• W419749922 cites W1973024069 @default.
• W419749922 cites W1973558989 @default.
• W419749922 cites W1975417628 @default.
• W419749922 cites W1976147329 @default.
• W419749922 cites W1976598196 @default.
• W419749922 cites W1977114987 @default.
• W419749922 cites W1977465442 @default.
• W419749922 cites W1977924236 @default.
• W419749922 cites W1978376724 @default.
• W419749922 cites W1979804408 @default.
• W419749922 cites W1980196077 @default.
• W419749922 cites W1980225319 @default.
• W419749922 cites W1981627398 @default.
• W419749922 cites W1982842107 @default.
• W419749922 cites W1983754627 @default.
• W419749922 cites W1984243311 @default.
• W419749922 cites W1985728966 @default.
• W419749922 cites W1991367158 @default.
• W419749922 cites W1992277524 @default.
• W419749922 cites W1992545390 @default.
• W419749922 cites W1994829259 @default.
• W419749922 cites W1995111040 @default.
• W419749922 cites W1995169343 @default.
• W419749922 cites W1996195151 @default.
• W419749922 cites W1996242554 @default.
• W419749922 cites W1997669140 @default.
• W419749922 cites W1998327866 @default.
• W419749922 cites W1998733397 @default.
• W419749922 cites W1999360185 @default.
• W419749922 cites W1999919402 @default.
• W419749922 cites W2000226539 @default.
• W419749922 cites W2001003983 @default.
• W419749922 cites W2001332122 @default.
• W419749922 cites W2001488773 @default.
• W419749922 cites W2001904553 @default.
• W419749922 cites W2002021029 @default.
• W419749922 cites W2003505635 @default.
• W419749922 cites W2005061021 @default.
• W419749922 cites W2006346200 @default.
• W419749922 cites W2006781562 @default.
• W419749922 cites W2007568800 @default.
• W419749922 cites W2008380962 @default.
• W419749922 cites W2008418208 @default.
• W419749922 cites W2008439504 @default.
• W419749922 cites W2008659515 @default.
• W419749922 cites W2008852244 @default.
• W419749922 cites W2010424677 @default.
• W419749922 cites W2010547854 @default.
• W419749922 cites W2010945210 @default.
• W419749922 cites W2012052528 @default.
• W419749922 cites W2014767017 @default.
• W419749922 cites W2015007231 @default.
• W419749922 cites W2016426141 @default.
• W419749922 cites W2016585607 @default.
• W419749922 cites W2016796835 @default.
• W419749922 cites W2017236051 @default.
• W419749922 cites W2017806432 @default.
• W419749922 cites W2018831302 @default.
• W419749922 cites W2019854455 @default.
• W419749922 cites W2020212968 @default.
• W419749922 cites W2021088559 @default.
• W419749922 cites W2021295182 @default.
• W419749922 cites W2022023762 @default.
• W419749922 cites W2022758750 @default.
• W419749922 cites W2023193193 @default.
• W419749922 cites W2024370389 @default.
• W419749922 cites W2025224539 @default.
• W419749922 cites W2025931876 @default.
• W419749922 cites W2025980850 @default.

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