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• W4200002015 abstract "<sec> <title>BACKGROUND</title> The present study was performed to determine the protective effects of Vitamin C, Zinc, and N-Acetylcysteine individually or in combinations with Cd, to monitor the amelioration capability against Cd-induced oxidative damage in Wistar rats. </sec> <sec> <title>OBJECTIVE</title> We investigated and demonstrated that Cadmium is a toxic element that damages rats' liver and kidney tissues. Vitamin C, Zinc, and NAC have been proven to have protective roles against Cd-toxic effects. </sec> <sec> <title>METHODS</title> Nine groups of rats were studied as the experimental group. The present experiment was conducted for 45 days. Liver and kidneys were excised for biochemical determinations by assaying antioxidant enzymes and lipid oxidation products to assess the impact of Cd-toxicity and its amelioration by co-administration of Vitamin C, Zinc, and NAC along with Cd. </sec> <sec> <title>RESULTS</title> Basal Metabolic rates and Tissue Respiration rates of liver and kidney significantly decreased (P < 0.05) during Cd toxicity. Serum biochemical parameters were also found to be significant altered to cope up with Cd toxicity. All the antioxidant enzymes and products were significant inhibited (P < 0.05) or elevated in rat liver and kidney tissues during Cd-induced toxicity. </sec> <sec> <title>CONCLUSIONS</title> Our results suggest a whereas with co-administration of Vitamin C, Zinc, and NAC, into rats demonstrate the amelioration of oxidative damage induced by Cd-toxicity. From the results obtained in the present study, all the agents tested had protective effects against Cd-induced oxidative damage. </sec> <sec> <title>CLINICALTRIAL</title> No </sec>" @default.
• W4200002015 created "2021-12-31" @default.
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• W4200002015 date "2021-11-10" @default.
• W4200002015 modified "2023-10-17" @default.
• W4200002015 title "Amelioration of Cadmium-induced oxidative damage in Wistar rats by Vitamin C, Zinc and N-Acetylcysteine (Preprint)" @default.
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• W4200002015 doi "https://doi.org/10.2196/preprints.34841" @default.
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