Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200003722> ?p ?o ?g. }
- W4200003722 endingPage "42" @default.
- W4200003722 startingPage "33" @default.
- W4200003722 abstract "Zearalenone is a mycotoxin and a pollutant that is commonly found in crops. Once ingested, ZEA can cause disturbances in the immune system and produce immunotoxicity. However, there is little research on the effect of ZEA exposure on the relationship between immune regulation and embryo implantation in the uteri of sows. Embryo implantation relies upon the fact that the relationship between the maternal and fetal immune systems is balanced. This balance is provided by the joint regulation of immune organs, cytokines, and uterine immunity. In this study, we investigated 20 sows with an initial weight of 100.00 ± 5.00 kg and 200 days in age. The sows were fed with diets containing ZEA at concentrations of 0 mg/kg, 1 mg/kg, 2 mg/kg, and 10 mg/kg, respectively, from 8 to 14 days of gestation. We studied immunotoxicity and the uterine transcriptomics associated with the effect of ZEA in sows during embryo attachment. Following ZEA treatment, serum biochemical analysis and RT-qPCR were used to detect the concentration and mRNA expression levels of immunoglobulin IgA, IgG, and IgM, in the serum and spleen, respectively. The same analysis was carried out for a range of cytokines in the serum and spleen: IL-1, IL-2, IL-6, IL-10, and TNF. Uterine transcriptome analysis revealed 75, 215, and 81 genes that were differentially expressed in the 0 mg/kg vs 1 mg/kg treatment, 0 mg/kg vs 10 mg/kg treatment, and 1 mg/kg vs 10 mg/kg treatment, respectively. GO terms analysis showed that the up-regulated genes related to the immune system were highly expressed. KEGG pathway analysis further revealed the importance of several metabolic pathways, including drug metabolism-cytochrome P450, the cytokine-cytokine receptor interaction pathway, and calcium signaling pathways. The differentially expressed genes were confirmed by quantitative real-time PCR. These findings expand our understanding of the gene expression profiles and signaling pathways associated with the immune response to ZEA exposure in sows during the embryo implantation window. This study provides valuable information for clarifying the molecular mechanism of ZEA's immunotoxicity to early pregnant sows in the future." @default.
- W4200003722 created "2021-12-31" @default.
- W4200003722 creator A5016214343 @default.
- W4200003722 creator A5025951806 @default.
- W4200003722 creator A5029713142 @default.
- W4200003722 creator A5045426904 @default.
- W4200003722 creator A5054789740 @default.
- W4200003722 creator A5055407864 @default.
- W4200003722 creator A5061436189 @default.
- W4200003722 creator A5064950632 @default.
- W4200003722 creator A5084756378 @default.
- W4200003722 date "2022-03-01" @default.
- W4200003722 modified "2023-10-16" @default.
- W4200003722 title "Immunotoxicity and uterine transcriptome analysis of the effect of zearalenone (ZEA) in sows during the embryo attachment period" @default.
- W4200003722 cites W1642366747 @default.
- W4200003722 cites W1829463977 @default.
- W4200003722 cites W1993866784 @default.
- W4200003722 cites W1998498869 @default.
- W4200003722 cites W2003937409 @default.
- W4200003722 cites W2014770610 @default.
- W4200003722 cites W2029572296 @default.
- W4200003722 cites W2033322771 @default.
- W4200003722 cites W2043593464 @default.
- W4200003722 cites W2049588822 @default.
- W4200003722 cites W2054186726 @default.
- W4200003722 cites W2071114508 @default.
- W4200003722 cites W2076840083 @default.
- W4200003722 cites W2102278945 @default.
- W4200003722 cites W2107060225 @default.
- W4200003722 cites W2113610605 @default.
- W4200003722 cites W2119034410 @default.
- W4200003722 cites W2141458291 @default.
- W4200003722 cites W2145879983 @default.
- W4200003722 cites W2165236774 @default.
- W4200003722 cites W2417118866 @default.
- W4200003722 cites W2462910504 @default.
- W4200003722 cites W2561502797 @default.
- W4200003722 cites W2568590844 @default.
- W4200003722 cites W2625800782 @default.
- W4200003722 cites W2736162745 @default.
- W4200003722 cites W2806092358 @default.
- W4200003722 cites W2806362973 @default.
- W4200003722 cites W2810034888 @default.
- W4200003722 cites W2922718355 @default.
- W4200003722 cites W2942463845 @default.
- W4200003722 cites W2979779137 @default.
- W4200003722 cites W2991479732 @default.
- W4200003722 cites W3012089592 @default.
- W4200003722 cites W3014272553 @default.
- W4200003722 cites W3034173398 @default.
- W4200003722 cites W3080619553 @default.
- W4200003722 cites W4211237594 @default.
- W4200003722 doi "https://doi.org/10.1016/j.toxlet.2021.12.017" @default.
- W4200003722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34933075" @default.
- W4200003722 hasPublicationYear "2022" @default.
- W4200003722 type Work @default.
- W4200003722 citedByCount "11" @default.
- W4200003722 countsByYear W42000037222022 @default.
- W4200003722 countsByYear W42000037222023 @default.
- W4200003722 crossrefType "journal-article" @default.
- W4200003722 hasAuthorship W4200003722A5016214343 @default.
- W4200003722 hasAuthorship W4200003722A5025951806 @default.
- W4200003722 hasAuthorship W4200003722A5029713142 @default.
- W4200003722 hasAuthorship W4200003722A5045426904 @default.
- W4200003722 hasAuthorship W4200003722A5054789740 @default.
- W4200003722 hasAuthorship W4200003722A5055407864 @default.
- W4200003722 hasAuthorship W4200003722A5061436189 @default.
- W4200003722 hasAuthorship W4200003722A5064950632 @default.
- W4200003722 hasAuthorship W4200003722A5084756378 @default.
- W4200003722 hasConcept C104317684 @default.
- W4200003722 hasConcept C126322002 @default.
- W4200003722 hasConcept C134018914 @default.
- W4200003722 hasConcept C150194340 @default.
- W4200003722 hasConcept C150903083 @default.
- W4200003722 hasConcept C162317418 @default.
- W4200003722 hasConcept C16685009 @default.
- W4200003722 hasConcept C172680121 @default.
- W4200003722 hasConcept C196843134 @default.
- W4200003722 hasConcept C203014093 @default.
- W4200003722 hasConcept C2777140777 @default.
- W4200003722 hasConcept C2779234561 @default.
- W4200003722 hasConcept C2780931953 @default.
- W4200003722 hasConcept C54355233 @default.
- W4200003722 hasConcept C55493867 @default.
- W4200003722 hasConcept C71924100 @default.
- W4200003722 hasConcept C84699730 @default.
- W4200003722 hasConcept C86803240 @default.
- W4200003722 hasConcept C8891405 @default.
- W4200003722 hasConcept C95444343 @default.
- W4200003722 hasConceptScore W4200003722C104317684 @default.
- W4200003722 hasConceptScore W4200003722C126322002 @default.
- W4200003722 hasConceptScore W4200003722C134018914 @default.
- W4200003722 hasConceptScore W4200003722C150194340 @default.
- W4200003722 hasConceptScore W4200003722C150903083 @default.
- W4200003722 hasConceptScore W4200003722C162317418 @default.
- W4200003722 hasConceptScore W4200003722C16685009 @default.
- W4200003722 hasConceptScore W4200003722C172680121 @default.
- W4200003722 hasConceptScore W4200003722C196843134 @default.