FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200004322> ?p ?o ?g. }

• W4200004322 endingPage "2141" @default.
• W4200004322 startingPage "2125" @default.
• W4200004322 abstract "Recently, it was demonstrated that doxorubicin (Dox.HCl), a chemotherapeutic agent, could be photoactivated by Cerenkov radiation (CR). The objective of the present work was to develop a multimodal chemotherapy-radiotherapy-photodynamic therapeutic system based on reconstituted high-density lipoprotein (rHDL) loaded with Dox.HCl and 177Lu-DOTA. 177Lu acts as a therapeutic radionuclide and CR source. The system can be visualized by nuclear imaging. Fluorescence microscopy showed that rHDL-Dox specifically recognized cancer cells (T47D) that are positive for SR-B1 receptors. Encapsulated Dox.HCl was released into the cells and produced reactive oxygen species when irradiated with a 450-nm laser (photodynamic effect). The same effect occurred when Dox.HCl was irradiated by 177Lu CR. Through in vitro experiments, it was confirmed that the addition of 177Lu-DOTA to the rHDL-Dox nanosystem did not affect the specific recognition of SR-B1 receptors expressed in cells, or the cellular internalization of 177Lu-DOTA. The toxicity induced by the rHDL-Dox/177Lu nanosystem in cell lines with high (T47D and PC3), poor (H9C2) and almost-zero (human fibroblasts (FB)) expression of SR-B1 was evaluated in vitro and confirmed the synergy of the combined chemotherapy-radiotherapy-photodynamic therapeutic effect; this induced toxicity was proportional to the expression of the SR-B1 receptor on the surface of the cells used. The HDL-Dox/177Lu nanosystem experienced uptake by tumor cells and the liver-both tissues with high expression of SR-B1 receptors-but not by the heart. 177Lu CR offered the possibility of imparting photodynamic therapy where laser light could not reach." @default.
• W4200004322 created "2021-12-31" @default.
• W4200004322 creator A5000294204 @default.
• W4200004322 creator A5002855256 @default.
• W4200004322 creator A5020732196 @default.
• W4200004322 creator A5023762195 @default.
• W4200004322 creator A5024431483 @default.
• W4200004322 creator A5031408302 @default.
• W4200004322 creator A5040070585 @default.
• W4200004322 creator A5040251027 @default.
• W4200004322 creator A5048486362 @default.
• W4200004322 creator A5049931686 @default.
• W4200004322 creator A5056543444 @default.
• W4200004322 creator A5062031676 @default.
• W4200004322 creator A5079122594 @default.
• W4200004322 creator A5084877491 @default.
• W4200004322 date "2021-11-01" @default.
• W4200004322 modified "2023-10-17" @default.
• W4200004322 title "A Multimodal Theranostic System Prepared from High-Density Lipoprotein Carrier of Doxorubicin and ¹⁷⁷Lu" @default.
• W4200004322 cites W1639509758 @default.
• W4200004322 cites W1981938979 @default.
• W4200004322 cites W2018066700 @default.
• W4200004322 cites W2039486449 @default.
• W4200004322 cites W2052373015 @default.
• W4200004322 cites W2056462125 @default.
• W4200004322 cites W2081910191 @default.
• W4200004322 cites W2105567749 @default.
• W4200004322 cites W2128147958 @default.
• W4200004322 cites W2176475325 @default.
• W4200004322 cites W2192905832 @default.
• W4200004322 cites W2295289052 @default.
• W4200004322 cites W2307983503 @default.
• W4200004322 cites W2505614715 @default.
• W4200004322 cites W2600596288 @default.
• W4200004322 cites W2620436731 @default.
• W4200004322 cites W2746151243 @default.
• W4200004322 cites W2754374643 @default.
• W4200004322 cites W2756313625 @default.
• W4200004322 cites W2787976484 @default.
• W4200004322 cites W2792308604 @default.
• W4200004322 cites W2900578305 @default.
• W4200004322 cites W3009123370 @default.
• W4200004322 cites W3165398119 @default.
• W4200004322 doi "https://doi.org/10.1166/jbn.2021.3179" @default.
• W4200004322 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34906274" @default.
• W4200004322 hasPublicationYear "2021" @default.
• W4200004322 type Work @default.
• W4200004322 citedByCount "5" @default.
• W4200004322 countsByYear W42000043222022 @default.
• W4200004322 countsByYear W42000043222023 @default.
• W4200004322 crossrefType "journal-article" @default.
• W4200004322 hasAuthorship W4200004322A5000294204 @default.
• W4200004322 hasAuthorship W4200004322A5002855256 @default.
• W4200004322 hasAuthorship W4200004322A5020732196 @default.
• W4200004322 hasAuthorship W4200004322A5023762195 @default.
• W4200004322 hasAuthorship W4200004322A5024431483 @default.
• W4200004322 hasAuthorship W4200004322A5031408302 @default.
• W4200004322 hasAuthorship W4200004322A5040070585 @default.
• W4200004322 hasAuthorship W4200004322A5040251027 @default.
• W4200004322 hasAuthorship W4200004322A5048486362 @default.
• W4200004322 hasAuthorship W4200004322A5049931686 @default.
• W4200004322 hasAuthorship W4200004322A5056543444 @default.
• W4200004322 hasAuthorship W4200004322A5062031676 @default.
• W4200004322 hasAuthorship W4200004322A5079122594 @default.
• W4200004322 hasAuthorship W4200004322A5084877491 @default.
• W4200004322 hasConcept C12554922 @default.
• W4200004322 hasConcept C126322002 @default.
• W4200004322 hasConcept C139770010 @default.
• W4200004322 hasConcept C170493617 @default.
• W4200004322 hasConcept C178790620 @default.
• W4200004322 hasConcept C185592680 @default.
• W4200004322 hasConcept C202751555 @default.
• W4200004322 hasConcept C2776694085 @default.
• W4200004322 hasConcept C2781303535 @default.
• W4200004322 hasConcept C2781323092 @default.
• W4200004322 hasConcept C29730261 @default.
• W4200004322 hasConcept C2989005 @default.
• W4200004322 hasConcept C2993559085 @default.
• W4200004322 hasConcept C502942594 @default.
• W4200004322 hasConcept C55493867 @default.
• W4200004322 hasConcept C71924100 @default.
• W4200004322 hasConcept C86803240 @default.
• W4200004322 hasConceptScore W4200004322C12554922 @default.
• W4200004322 hasConceptScore W4200004322C126322002 @default.
• W4200004322 hasConceptScore W4200004322C139770010 @default.
• W4200004322 hasConceptScore W4200004322C170493617 @default.
• W4200004322 hasConceptScore W4200004322C178790620 @default.
• W4200004322 hasConceptScore W4200004322C185592680 @default.
• W4200004322 hasConceptScore W4200004322C202751555 @default.
• W4200004322 hasConceptScore W4200004322C2776694085 @default.
• W4200004322 hasConceptScore W4200004322C2781303535 @default.
• W4200004322 hasConceptScore W4200004322C2781323092 @default.
• W4200004322 hasConceptScore W4200004322C29730261 @default.
• W4200004322 hasConceptScore W4200004322C2989005 @default.
• W4200004322 hasConceptScore W4200004322C2993559085 @default.
• W4200004322 hasConceptScore W4200004322C502942594 @default.
• W4200004322 hasConceptScore W4200004322C55493867 @default.
• W4200004322 hasConceptScore W4200004322C71924100 @default.

• next