Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200005058> ?p ?o ?g. }
- W4200005058 endingPage "3442" @default.
- W4200005058 startingPage "3442" @default.
- W4200005058 abstract "In day-to-day life, we often choose between pursuing familiar behaviors that have been rewarded in the past or adjusting behaviors when new strategies might be more fruitful. The dorsomedial striatum (DMS) is indispensable for flexibly arbitrating between old and new behavioral strategies. The way in which DMS neurons host stable connections necessary for sustained flexibility is still being defined. An entry point to addressing this question may be the structural scaffolds on DMS neurons that house synaptic connections. We find that the non-receptor tyrosine kinase Proline-rich tyrosine kinase 2 (Pyk2) stabilizes both dendrites and spines on striatal medium spiny neurons, such that Pyk2 loss causes dendrite arbor and spine loss. Viral-mediated Pyk2 silencing in the DMS obstructs the ability of mice to arbitrate between rewarded and non-rewarded behaviors. Meanwhile, the overexpression of Pyk2 or the closely related focal adhesion kinase (FAK) enhances this ability. Finally, experiments using combinatorial viral vector strategies suggest that flexible, Pyk2-dependent action involves inputs from the medial prefrontal cortex (mPFC), but not the ventrolateral orbitofrontal cortex (OFC). Thus, Pyk2 stabilizes the striatal medium spiny neuron structure, likely providing substrates for inputs, and supports the capacity of mice to arbitrate between novel and familiar behaviors, including via interactions with the medial-prefrontal cortex." @default.
- W4200005058 created "2021-12-31" @default.
- W4200005058 creator A5011853797 @default.
- W4200005058 creator A5042353099 @default.
- W4200005058 creator A5048138803 @default.
- W4200005058 creator A5062045407 @default.
- W4200005058 date "2021-12-07" @default.
- W4200005058 modified "2023-10-16" @default.
- W4200005058 title "Pyk2 Stabilizes Striatal Medium Spiny Neuron Structure and Striatal-Dependent Action" @default.
- W4200005058 cites W1495117058 @default.
- W4200005058 cites W1906573763 @default.
- W4200005058 cites W1936785944 @default.
- W4200005058 cites W1967332557 @default.
- W4200005058 cites W1969352183 @default.
- W4200005058 cites W1987208997 @default.
- W4200005058 cites W1991174296 @default.
- W4200005058 cites W1998476901 @default.
- W4200005058 cites W2010860074 @default.
- W4200005058 cites W2020689320 @default.
- W4200005058 cites W2024717330 @default.
- W4200005058 cites W2027101052 @default.
- W4200005058 cites W2061863046 @default.
- W4200005058 cites W2064676382 @default.
- W4200005058 cites W2071534328 @default.
- W4200005058 cites W2072305222 @default.
- W4200005058 cites W2073236029 @default.
- W4200005058 cites W2083537735 @default.
- W4200005058 cites W2102754843 @default.
- W4200005058 cites W2107476842 @default.
- W4200005058 cites W2107522794 @default.
- W4200005058 cites W2113392896 @default.
- W4200005058 cites W2122643181 @default.
- W4200005058 cites W2127810309 @default.
- W4200005058 cites W2142150505 @default.
- W4200005058 cites W2156257459 @default.
- W4200005058 cites W2171277642 @default.
- W4200005058 cites W2247895703 @default.
- W4200005058 cites W2337587895 @default.
- W4200005058 cites W2344235711 @default.
- W4200005058 cites W2345112163 @default.
- W4200005058 cites W2406024906 @default.
- W4200005058 cites W2495117617 @default.
- W4200005058 cites W2520319850 @default.
- W4200005058 cites W2528995936 @default.
- W4200005058 cites W2619291451 @default.
- W4200005058 cites W2726331523 @default.
- W4200005058 cites W2745223669 @default.
- W4200005058 cites W2769197797 @default.
- W4200005058 cites W2788498787 @default.
- W4200005058 cites W2791690085 @default.
- W4200005058 cites W2806548405 @default.
- W4200005058 cites W2809694683 @default.
- W4200005058 cites W2889314641 @default.
- W4200005058 cites W2902154838 @default.
- W4200005058 cites W2903580842 @default.
- W4200005058 cites W2909808142 @default.
- W4200005058 cites W2914832532 @default.
- W4200005058 cites W2916879070 @default.
- W4200005058 cites W2932123934 @default.
- W4200005058 cites W2932309265 @default.
- W4200005058 cites W2947386925 @default.
- W4200005058 cites W2958148856 @default.
- W4200005058 cites W2966019190 @default.
- W4200005058 cites W2996334051 @default.
- W4200005058 cites W3003973921 @default.
- W4200005058 cites W3016805884 @default.
- W4200005058 cites W3018681153 @default.
- W4200005058 cites W3118170080 @default.
- W4200005058 cites W3164484537 @default.
- W4200005058 cites W3176985371 @default.
- W4200005058 cites W4242705134 @default.
- W4200005058 doi "https://doi.org/10.3390/cells10123442" @default.
- W4200005058 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34943950" @default.
- W4200005058 hasPublicationYear "2021" @default.
- W4200005058 type Work @default.
- W4200005058 citedByCount "1" @default.
- W4200005058 countsByYear W42000050582022 @default.
- W4200005058 crossrefType "journal-article" @default.
- W4200005058 hasAuthorship W4200005058A5011853797 @default.
- W4200005058 hasAuthorship W4200005058A5042353099 @default.
- W4200005058 hasAuthorship W4200005058A5048138803 @default.
- W4200005058 hasAuthorship W4200005058A5062045407 @default.
- W4200005058 hasBestOaLocation W42000050581 @default.
- W4200005058 hasConcept C169760540 @default.
- W4200005058 hasConcept C169900460 @default.
- W4200005058 hasConcept C2778794669 @default.
- W4200005058 hasConcept C2780062018 @default.
- W4200005058 hasConcept C2781195155 @default.
- W4200005058 hasConcept C513476851 @default.
- W4200005058 hasConcept C85714458 @default.
- W4200005058 hasConcept C86803240 @default.
- W4200005058 hasConceptScore W4200005058C169760540 @default.
- W4200005058 hasConceptScore W4200005058C169900460 @default.
- W4200005058 hasConceptScore W4200005058C2778794669 @default.
- W4200005058 hasConceptScore W4200005058C2780062018 @default.
- W4200005058 hasConceptScore W4200005058C2781195155 @default.
- W4200005058 hasConceptScore W4200005058C513476851 @default.
- W4200005058 hasConceptScore W4200005058C85714458 @default.