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- W4200005275 abstract "Malformations of cortical development (MCDs) are structural anomalies that disrupt the normal process of cortical development. These include microcephaly with simplified gyral pattern/microlissencephaly, hemimegalencephaly, focal cortical dysplasia, lissencephaly, heterotopia, polymicrogyria, and schizencephaly. They can present with intractable epilepsy, developmental delay, neurologic deficits, or cognitive impairment. Though the definitive diagnosis of MCD depends on histopathology, the pathologic tissue is rarely available; hence diagnosis begins with neuroimaging. This article shall briefly review the embryology, followed by specific magnetic resonance imaging features of MCD in an attempt to simplify the process of diagnosing these disorders with clinical and genetic correlation. A table has been included to highlight the embryologic, clinical, and genetic findings associated with various MCDs." @default.
- W4200005275 created "2021-12-31" @default.
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- W4200005275 date "2022-03-01" @default.
- W4200005275 modified "2023-10-17" @default.
- W4200005275 title "Magnetic Resonance Imaging of Malformations of Cortical Development—A Comprehensive Review" @default.
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- W4200005275 doi "https://doi.org/10.1016/j.wneu.2021.12.011" @default.
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