FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200007687> ?p ?o ?g. }

• W4200007687 abstract "High glucose (HG) is linked to dopaminergic neuron loss and related Parkinson's disease (PD), but the mechanism is unclear.Rats and differentiated SH-SY5Y cells were used to investigate the effect of HG on dopaminergic neuronal apoptotic death. We found that a 40-day HG diet elevated cleaved caspase 3 levels and activated Fyn and mTOR/S6K signaling in the substantia nigra of rats. In vitro, 6 days of HG treatment activated Fyn, enhanced binding between Fyn and mTOR, activated mTOR/S6K signaling, and induced neuronal apoptotic death. The proapoptotic effect of HG was rescued by either the Fyn inhibitor PP1 or the mTOR inhibitor rapamycin. PP1 inhibited mTOR/S6K signaling, but rapamycin was unable to modulate Fyn activation.HG induces dopaminergic neuronal apoptotic death via the Fyn/mTOR/S6K pathway." @default.
• W4200007687 created "2021-12-31" @default.
• W4200007687 creator A5006549177 @default.
• W4200007687 creator A5011372526 @default.
• W4200007687 creator A5026966243 @default.
• W4200007687 creator A5030528659 @default.
• W4200007687 creator A5030780126 @default.
• W4200007687 creator A5049057154 @default.
• W4200007687 creator A5062736063 @default.
• W4200007687 creator A5064013442 @default.
• W4200007687 creator A5083247969 @default.
• W4200007687 creator A5090366405 @default.
• W4200007687 date "2021-12-01" @default.
• W4200007687 modified "2023-10-18" @default.
• W4200007687 title "Fyn kinase regulates dopaminergic neuronal apoptosis in animal and cell models of high glucose (HG) treatment" @default.
• W4200007687 cites W1858632601 @default.
• W4200007687 cites W1947879644 @default.
• W4200007687 cites W1965575645 @default.
• W4200007687 cites W1976118830 @default.
• W4200007687 cites W2015975538 @default.
• W4200007687 cites W2026969412 @default.
• W4200007687 cites W2027189759 @default.
• W4200007687 cites W2029241688 @default.
• W4200007687 cites W2048288736 @default.
• W4200007687 cites W2051729750 @default.
• W4200007687 cites W2062686313 @default.
• W4200007687 cites W2063980028 @default.
• W4200007687 cites W2065165825 @default.
• W4200007687 cites W2082905129 @default.
• W4200007687 cites W2090012352 @default.
• W4200007687 cites W2092780698 @default.
• W4200007687 cites W2096298540 @default.
• W4200007687 cites W2114570899 @default.
• W4200007687 cites W2127558621 @default.
• W4200007687 cites W2151704931 @default.
• W4200007687 cites W2157198061 @default.
• W4200007687 cites W2165021720 @default.
• W4200007687 cites W216902405 @default.
• W4200007687 cites W2224447222 @default.
• W4200007687 cites W2401820359 @default.
• W4200007687 cites W2581824660 @default.
• W4200007687 cites W2604224100 @default.
• W4200007687 cites W2621833135 @default.
• W4200007687 cites W2743996592 @default.
• W4200007687 cites W2751201591 @default.
• W4200007687 cites W2771649136 @default.
• W4200007687 cites W2793373062 @default.
• W4200007687 cites W2803912806 @default.
• W4200007687 cites W2888470279 @default.
• W4200007687 cites W2893367785 @default.
• W4200007687 cites W2897730105 @default.
• W4200007687 cites W2901737658 @default.
• W4200007687 cites W2913192471 @default.
• W4200007687 cites W2942726688 @default.
• W4200007687 cites W3005397748 @default.
• W4200007687 cites W3036011811 @default.
• W4200007687 cites W3039563353 @default.
• W4200007687 cites W307587437 @default.
• W4200007687 cites W4211123396 @default.
• W4200007687 cites W4211240576 @default.
• W4200007687 cites W46184420 @default.
• W4200007687 doi "https://doi.org/10.1186/s12860-021-00398-y" @default.
• W4200007687 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34863087" @default.
• W4200007687 hasPublicationYear "2021" @default.
• W4200007687 type Work @default.
• W4200007687 citedByCount "0" @default.
• W4200007687 crossrefType "journal-article" @default.
• W4200007687 hasAuthorship W4200007687A5006549177 @default.
• W4200007687 hasAuthorship W4200007687A5011372526 @default.
• W4200007687 hasAuthorship W4200007687A5026966243 @default.
• W4200007687 hasAuthorship W4200007687A5030528659 @default.
• W4200007687 hasAuthorship W4200007687A5030780126 @default.
• W4200007687 hasAuthorship W4200007687A5049057154 @default.
• W4200007687 hasAuthorship W4200007687A5062736063 @default.
• W4200007687 hasAuthorship W4200007687A5064013442 @default.
• W4200007687 hasAuthorship W4200007687A5083247969 @default.
• W4200007687 hasAuthorship W4200007687A5090366405 @default.
• W4200007687 hasBestOaLocation W42000076871 @default.
• W4200007687 hasConcept C104202773 @default.
• W4200007687 hasConcept C108636557 @default.
• W4200007687 hasConcept C134018914 @default.
• W4200007687 hasConcept C137183658 @default.
• W4200007687 hasConcept C185592680 @default.
• W4200007687 hasConcept C190283241 @default.
• W4200007687 hasConcept C2780938664 @default.
• W4200007687 hasConcept C31573885 @default.
• W4200007687 hasConcept C37686147 @default.
• W4200007687 hasConcept C502942594 @default.
• W4200007687 hasConcept C513476851 @default.
• W4200007687 hasConcept C55493867 @default.
• W4200007687 hasConcept C62478195 @default.
• W4200007687 hasConcept C86554907 @default.
• W4200007687 hasConcept C86803240 @default.
• W4200007687 hasConcept C95444343 @default.
• W4200007687 hasConceptScore W4200007687C104202773 @default.
• W4200007687 hasConceptScore W4200007687C108636557 @default.
• W4200007687 hasConceptScore W4200007687C134018914 @default.
• W4200007687 hasConceptScore W4200007687C137183658 @default.
• W4200007687 hasConceptScore W4200007687C185592680 @default.
• W4200007687 hasConceptScore W4200007687C190283241 @default.

• next