FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200009886> ?p ?o ?g. }

• W4200009886 endingPage "81" @default.
• W4200009886 startingPage "66" @default.
• W4200009886 abstract "Obstructive sleep apnea (OSA), characterized by low arterial oxygen saturation during sleep, is associated with an increased risk of orofacial pain. In this study, we simulated chronic intermittent hypoxia (CIH) during the sleep/rest phase (light phase) to determine the role of transient receptor potential vanilloid 1 (TRPV1) in mediating enhanced orofacial nocifensive behavior and trigeminal spinal subnucleus caudalis (Vc) neuronal responses to capsaicin (a TRPV1 agonist) stimulation in a rat model of OSA. Rats were subjected to CIH (nadir O2, 5%) during the light phase for 8 or 16 consecutive days. CIH yielded enhanced behavioral responses to capsaicin after application to the ocular surface and intraoral mucosa, which was reversed under normoxic conditions. The percentage of TRPV1-immunoreactive trigeminal ganglion neurons was greater in CIH rats than in normoxic rats and recovered under normoxic conditions after CIH. The ratio of large-sized TRPV1-immunoreactive trigeminal ganglion neurons increased in CIH rats. The density of TRPV1 positive primary afferent terminals in the superficial laminae of Vc was higher in CIH rats. Phosphorylated extracellular signal-regulated kinase (pERK)-immunoreactive cells intermingled with the central terminal of TRPV1-positive afferents in the Vc. The number of pERK-immunoreactive cells following low-dose capsaicin (0.33 µM) application to the tongue was significantly greater in the middle portion of the Vc of CIH rats than of normoxic rats and recovered under normoxic conditions after CIH. These data suggest that CIH during the sleep (light) phase is sufficient to transiently enhance pain on the ocular surface and intraoral mucosa via TRPV1-dependent mechanisms." @default.
• W4200009886 created "2021-12-31" @default.
• W4200009886 creator A5000891804 @default.
• W4200009886 creator A5010787284 @default.
• W4200009886 creator A5022750117 @default.
• W4200009886 creator A5029037864 @default.
• W4200009886 creator A5055789322 @default.
• W4200009886 creator A5056722416 @default.
• W4200009886 creator A5064949815 @default.
• W4200009886 creator A5079169974 @default.
• W4200009886 creator A5087394683 @default.
• W4200009886 date "2022-02-01" @default.
• W4200009886 modified "2023-09-26" @default.
• W4200009886 title "Enhanced Ocular Surface and Intraoral Nociception via a Transient Receptor Potential Vanilloid 1 Mechanism in a Rat Model of Obstructive Sleep Apnea" @default.
• W4200009886 cites W113950690 @default.
• W4200009886 cites W1509240027 @default.
• W4200009886 cites W1511198581 @default.
• W4200009886 cites W1919664406 @default.
• W4200009886 cites W1928547908 @default.
• W4200009886 cites W1963680271 @default.
• W4200009886 cites W1963777623 @default.
• W4200009886 cites W1964045215 @default.
• W4200009886 cites W1964563529 @default.
• W4200009886 cites W1973349996 @default.
• W4200009886 cites W1975140503 @default.
• W4200009886 cites W1993332998 @default.
• W4200009886 cites W1995642991 @default.
• W4200009886 cites W1995971403 @default.
• W4200009886 cites W1996723516 @default.
• W4200009886 cites W1996966053 @default.
• W4200009886 cites W1998358427 @default.
• W4200009886 cites W1998787695 @default.
• W4200009886 cites W1999335215 @default.
• W4200009886 cites W2005396232 @default.
• W4200009886 cites W2020226714 @default.
• W4200009886 cites W2022386219 @default.
• W4200009886 cites W2023752710 @default.
• W4200009886 cites W2024509945 @default.
• W4200009886 cites W2028967953 @default.
• W4200009886 cites W2029015778 @default.
• W4200009886 cites W2033308881 @default.
• W4200009886 cites W2033337525 @default.
• W4200009886 cites W2034576125 @default.
• W4200009886 cites W2036666857 @default.
• W4200009886 cites W2041623224 @default.
• W4200009886 cites W2042690759 @default.
• W4200009886 cites W2045185313 @default.
• W4200009886 cites W2046415975 @default.
• W4200009886 cites W2055031029 @default.
• W4200009886 cites W2063543894 @default.
• W4200009886 cites W2063821082 @default.
• W4200009886 cites W2068764539 @default.
• W4200009886 cites W2074024751 @default.
• W4200009886 cites W2076975188 @default.
• W4200009886 cites W2079621726 @default.
• W4200009886 cites W2082070599 @default.
• W4200009886 cites W2093708130 @default.
• W4200009886 cites W2107705149 @default.
• W4200009886 cites W2115785038 @default.
• W4200009886 cites W2124591307 @default.
• W4200009886 cites W2126816876 @default.
• W4200009886 cites W2134010823 @default.
• W4200009886 cites W2147971118 @default.
• W4200009886 cites W2148957877 @default.
• W4200009886 cites W2165623186 @default.
• W4200009886 cites W2170291000 @default.
• W4200009886 cites W23711947 @default.
• W4200009886 cites W2522113451 @default.
• W4200009886 cites W2524444926 @default.
• W4200009886 cites W2597931793 @default.
• W4200009886 cites W2602027544 @default.
• W4200009886 cites W2604958442 @default.
• W4200009886 cites W2621552279 @default.
• W4200009886 cites W2747633746 @default.
• W4200009886 cites W2767493153 @default.
• W4200009886 cites W2800878325 @default.
• W4200009886 cites W2884548335 @default.
• W4200009886 cites W2899516391 @default.
• W4200009886 cites W2902885506 @default.
• W4200009886 cites W2914747889 @default.
• W4200009886 cites W2914961860 @default.
• W4200009886 cites W2959442417 @default.
• W4200009886 cites W2991006700 @default.
• W4200009886 cites W3000047497 @default.
• W4200009886 cites W3001999902 @default.
• W4200009886 cites W3028313561 @default.
• W4200009886 cites W3038634685 @default.
• W4200009886 cites W3045204456 @default.
• W4200009886 cites W3086593701 @default.
• W4200009886 cites W3093104686 @default.
• W4200009886 cites W3122431730 @default.
• W4200009886 cites W3124922969 @default.
• W4200009886 cites W3135388061 @default.
• W4200009886 cites W3548815 @default.
• W4200009886 cites W4236357753 @default.
• W4200009886 cites W838823162 @default.
• W4200009886 doi "https://doi.org/10.1016/j.neuroscience.2021.12.002" @default.
• W4200009886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34883200" @default.

• next