FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200010248> ?p ?o ?g. }

• W4200010248 abstract "Although there are standard treatment options for osteosarcoma (OS), the prognoses of patients with OS remain varied. Therefore, it is important to profile OS patients at a high risk of mortality to develop focused interventions. Although tumor biomarkers are closely associated with clinical outcomes, data on prognostic biomarkers for OS remain scarce.We collected RNA expression profiles and clinical data of 90 OS patients from the GEO database (dataset GSE21257 and GSE39055) and 96 patients in the TARGET program. The data were analyzed using univariate Kaplan-Meier survival analysis to screen candidate gene sets that might be associated with OS survival.Our analysis demonstrated that melanoma cell adhesion molecule (MCAM) was associated with overall survival of patients with OS in the three cohorts. The data showed that MCAM was upregulated in OS patients who had metastases within 5 years compared to those without metastases. GO analysis revealed that genes correlated with MCAM were mainly involved in cell migration and wound healing processes. In addition, wound healing assays and gene set enrichment analysis results from RNA sequencing data of small interfering (si)-MCAM-transfected OS cells demonstrated that MCAM modulated tumor cell migration.Our data demonstrate that MCAM may be a novel prognostic biomarker for OS. MCAM is associated with increased cell migration ability and risk of metastasis, thus leading to poor prognoses in OS patients." @default.
• W4200010248 created "2021-12-31" @default.
• W4200010248 creator A5011645302 @default.
• W4200010248 creator A5011722589 @default.
• W4200010248 creator A5033632697 @default.
• W4200010248 creator A5063127492 @default.
• W4200010248 creator A5075969066 @default.
• W4200010248 date "2021-12-27" @default.
• W4200010248 modified "2023-09-26" @default.
• W4200010248 title "<i>MCAM</i> is associated with metastasis and poor prognosis in osteosarcoma by modulating tumor cell migration" @default.
• W4200010248 cites W1744787733 @default.
• W4200010248 cites W1761998660 @default.
• W4200010248 cites W1971133147 @default.
• W4200010248 cites W1973751980 @default.
• W4200010248 cites W1988325237 @default.
• W4200010248 cites W1995370402 @default.
• W4200010248 cites W2015514392 @default.
• W4200010248 cites W2019080218 @default.
• W4200010248 cites W2031252019 @default.
• W4200010248 cites W2033022462 @default.
• W4200010248 cites W2045518593 @default.
• W4200010248 cites W2072147226 @default.
• W4200010248 cites W2079047574 @default.
• W4200010248 cites W2094320065 @default.
• W4200010248 cites W2094678200 @default.
• W4200010248 cites W2101322033 @default.
• W4200010248 cites W2106409672 @default.
• W4200010248 cites W2108661706 @default.
• W4200010248 cites W2114840669 @default.
• W4200010248 cites W2116599555 @default.
• W4200010248 cites W2120413582 @default.
• W4200010248 cites W2139773658 @default.
• W4200010248 cites W2148077417 @default.
• W4200010248 cites W2149243808 @default.
• W4200010248 cites W2153898423 @default.
• W4200010248 cites W2273998766 @default.
• W4200010248 cites W2288728207 @default.
• W4200010248 cites W2461708130 @default.
• W4200010248 cites W2463180010 @default.
• W4200010248 cites W2535143162 @default.
• W4200010248 cites W2549002795 @default.
• W4200010248 cites W2600572285 @default.
• W4200010248 cites W2730108707 @default.
• W4200010248 cites W2773653224 @default.
• W4200010248 cites W2901259053 @default.
• W4200010248 cites W2918039882 @default.
• W4200010248 cites W2983188381 @default.
• W4200010248 cites W2997843311 @default.
• W4200010248 cites W4200010248 @default.
• W4200010248 cites W4246742253 @default.
• W4200010248 doi "https://doi.org/10.1002/jcla.24214" @default.
• W4200010248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34961985" @default.
• W4200010248 hasPublicationYear "2021" @default.
• W4200010248 type Work @default.
• W4200010248 citedByCount "3" @default.
• W4200010248 countsByYear W42000102482021 @default.
• W4200010248 countsByYear W42000102482022 @default.
• W4200010248 crossrefType "journal-article" @default.
• W4200010248 hasAuthorship W4200010248A5011645302 @default.
• W4200010248 hasAuthorship W4200010248A5011722589 @default.
• W4200010248 hasAuthorship W4200010248A5033632697 @default.
• W4200010248 hasAuthorship W4200010248A5063127492 @default.
• W4200010248 hasAuthorship W4200010248A5075969066 @default.
• W4200010248 hasBestOaLocation W42000102482 @default.
• W4200010248 hasConcept C121608353 @default.
• W4200010248 hasConcept C126322002 @default.
• W4200010248 hasConcept C137738243 @default.
• W4200010248 hasConcept C143998085 @default.
• W4200010248 hasConcept C144301174 @default.
• W4200010248 hasConcept C1491633281 @default.
• W4200010248 hasConcept C2779013556 @default.
• W4200010248 hasConcept C2781197716 @default.
• W4200010248 hasConcept C38180746 @default.
• W4200010248 hasConcept C502942594 @default.
• W4200010248 hasConcept C54355233 @default.
• W4200010248 hasConcept C55493867 @default.
• W4200010248 hasConcept C71924100 @default.
• W4200010248 hasConcept C86803240 @default.
• W4200010248 hasConceptScore W4200010248C121608353 @default.
• W4200010248 hasConceptScore W4200010248C126322002 @default.
• W4200010248 hasConceptScore W4200010248C137738243 @default.
• W4200010248 hasConceptScore W4200010248C143998085 @default.
• W4200010248 hasConceptScore W4200010248C144301174 @default.
• W4200010248 hasConceptScore W4200010248C1491633281 @default.
• W4200010248 hasConceptScore W4200010248C2779013556 @default.
• W4200010248 hasConceptScore W4200010248C2781197716 @default.
• W4200010248 hasConceptScore W4200010248C38180746 @default.
• W4200010248 hasConceptScore W4200010248C502942594 @default.
• W4200010248 hasConceptScore W4200010248C54355233 @default.
• W4200010248 hasConceptScore W4200010248C55493867 @default.
• W4200010248 hasConceptScore W4200010248C71924100 @default.
• W4200010248 hasConceptScore W4200010248C86803240 @default.
• W4200010248 hasFunder F4320321001 @default.
• W4200010248 hasIssue "2" @default.
• W4200010248 hasLocation W42000102481 @default.
• W4200010248 hasLocation W42000102482 @default.
• W4200010248 hasLocation W42000102483 @default.
• W4200010248 hasOpenAccess W4200010248 @default.
• W4200010248 hasPrimaryLocation W42000102481 @default.
• W4200010248 hasRelatedWork W1499339123 @default.

• next