Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200012810> ?p ?o ?g. }
- W4200012810 endingPage "462" @default.
- W4200012810 startingPage "457" @default.
- W4200012810 abstract "Although statins are effective in secondary prevention of ischemic stroke, they are also associated with an increase risk of intracranial hemorrhage (ICH) in certain conditions. In the TST trial (Treat Stroke to Target), we prespecified an exploration of the predictors of incident ICH.Patients with ischemic stroke in the previous 3 months or transient ischemic attack within the previous 15 days and evidence of cerebrovascular or coronary artery atherosclerosis were randomly assigned in a 1:1 ratio to a target LDL (low-density lipoprotein) cholesterol of <70 mg/dL or 100±10 mg/dL, using statin or ezetimibe.Among 2860 patients enrolled, 31 incident ICH occurred over a median follow-up of 3 years (18 and 13 in the lower and higher target group, 3.21/1000 patient-years [95% CI, 2.38-4.04] and 2.32/1000 patient-years [95% CI, 1.61-3.03], respectively). While there were no baseline predictors of ICH, uncontrolled hypertension (HR, 2.51 [95% CI, 1.01-6.31], P=0.041) and being on anticoagulant (HR, 2.36 [95% CI, 1.00-5.62], P=0.047)] during the trial were significant predictors. On-treatment low LDL cholesterol was not a predictor of ICH.Targeting an LDL cholesterol of <70 mg/dL compared with 100±10 mg/dL in patients with atherosclerotic ischemic stroke nonsignificantly increased the risk of ICH. Incident ICHs were not associated with low LDL cholesterol. Uncontrolled hypertension and anticoagulant therapy were associated with ICH which has important clinical implications. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT01252875; EUDRACT identifier: 2009-A01280-57." @default.
- W4200012810 created "2021-12-31" @default.
- W4200012810 creator A5000719185 @default.
- W4200012810 creator A5002952685 @default.
- W4200012810 creator A5005580042 @default.
- W4200012810 creator A5005743781 @default.
- W4200012810 creator A5006348628 @default.
- W4200012810 creator A5006754238 @default.
- W4200012810 creator A5007054935 @default.
- W4200012810 creator A5009889107 @default.
- W4200012810 creator A5011251946 @default.
- W4200012810 creator A5013166256 @default.
- W4200012810 creator A5014550188 @default.
- W4200012810 creator A5015335053 @default.
- W4200012810 creator A5015845166 @default.
- W4200012810 creator A5015908820 @default.
- W4200012810 creator A5018387285 @default.
- W4200012810 creator A5019241162 @default.
- W4200012810 creator A5019925456 @default.
- W4200012810 creator A5021546759 @default.
- W4200012810 creator A5022119086 @default.
- W4200012810 creator A5023091399 @default.
- W4200012810 creator A5023987721 @default.
- W4200012810 creator A5026089049 @default.
- W4200012810 creator A5026157924 @default.
- W4200012810 creator A5026919375 @default.
- W4200012810 creator A5027995760 @default.
- W4200012810 creator A5028314109 @default.
- W4200012810 creator A5028334445 @default.
- W4200012810 creator A5030028393 @default.
- W4200012810 creator A5030781961 @default.
- W4200012810 creator A5031259642 @default.
- W4200012810 creator A5031418735 @default.
- W4200012810 creator A5032094351 @default.
- W4200012810 creator A5032836573 @default.
- W4200012810 creator A5033574822 @default.
- W4200012810 creator A5034286418 @default.
- W4200012810 creator A5034753505 @default.
- W4200012810 creator A5037492217 @default.
- W4200012810 creator A5038599162 @default.
- W4200012810 creator A5040334802 @default.
- W4200012810 creator A5041789075 @default.
- W4200012810 creator A5043340930 @default.
- W4200012810 creator A5044000211 @default.
- W4200012810 creator A5045417835 @default.
- W4200012810 creator A5046239431 @default.
- W4200012810 creator A5047319689 @default.
- W4200012810 creator A5047397326 @default.
- W4200012810 creator A5048697514 @default.
- W4200012810 creator A5048979802 @default.
- W4200012810 creator A5049520768 @default.
- W4200012810 creator A5049975927 @default.
- W4200012810 creator A5052743842 @default.
- W4200012810 creator A5053465620 @default.
- W4200012810 creator A5054255276 @default.
- W4200012810 creator A5054790595 @default.
- W4200012810 creator A5055596681 @default.
- W4200012810 creator A5056531006 @default.
- W4200012810 creator A5059706651 @default.
- W4200012810 creator A5060519299 @default.
- W4200012810 creator A5060919206 @default.
- W4200012810 creator A5062415817 @default.
- W4200012810 creator A5062973701 @default.
- W4200012810 creator A5063859581 @default.
- W4200012810 creator A5064275544 @default.
- W4200012810 creator A5064418982 @default.
- W4200012810 creator A5065885814 @default.
- W4200012810 creator A5066015299 @default.
- W4200012810 creator A5066863496 @default.
- W4200012810 creator A5067579242 @default.
- W4200012810 creator A5067656534 @default.
- W4200012810 creator A5069730524 @default.
- W4200012810 creator A5070249324 @default.
- W4200012810 creator A5070491910 @default.
- W4200012810 creator A5071378860 @default.
- W4200012810 creator A5071631063 @default.
- W4200012810 creator A5071966452 @default.
- W4200012810 creator A5074688971 @default.
- W4200012810 creator A5075211364 @default.
- W4200012810 creator A5077224940 @default.
- W4200012810 creator A5077439822 @default.
- W4200012810 creator A5078825588 @default.
- W4200012810 creator A5079384149 @default.
- W4200012810 creator A5080288226 @default.
- W4200012810 creator A5082163781 @default.
- W4200012810 creator A5082524915 @default.
- W4200012810 creator A5083025416 @default.
- W4200012810 creator A5083918466 @default.
- W4200012810 creator A5084261634 @default.
- W4200012810 creator A5084546094 @default.
- W4200012810 creator A5087259111 @default.
- W4200012810 creator A5088096181 @default.
- W4200012810 creator A5090096595 @default.
- W4200012810 creator A5090244455 @default.
- W4200012810 creator A5091344772 @default.
- W4200012810 creator A5091421366 @default.
- W4200012810 creator A5091894359 @default.
- W4200012810 creator A5034568251 @default.