Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200014774> ?p ?o ?g. }
Showing items 1 to 50 of
50
with 100 items per page.
- W4200014774 abstract "<p>The development of new vaccines to respond to infectious diseases requires new vaccine adjuvants, which improve vaccine efficacy and shape the immune response. Trehalose glycolipids, consisting of α,α'-trehalose esterified at the 6- and 6'- positions with lipids, exhibit adjuvant activity by binding and activating Macrophage inducible C-type lectin (Mincle). However, the adjuvant activity of trehalose glycolipids could potentially be improved by substituting the ester linkages for more physiologically stable amide bonds. This thesis presents a short protecting group free route to trehalose amide glycolipids, thus allowing for the synthesis of the straight chain glycolipid amides 1a-e in four steps and in excellent (53-61%) overall yields (Figure 1). Amide glycolipids 1a-e were demonstrated to be Mincle agonists with comparable activity to their ester counterparts, as determined using a green fluorescent protein (GFP) reporter cell line assay. A second generation of trehalose amide glycolipids, the lipidated brartemicin amide analogues 2a-c, were subsequently synthesised (Figure 1). This report is the first example of trehalose amide glycolipids acting as Mincle agonists, and further studies into the potential of the amides as vaccine adjuvants will be undertaken in due course.</p>" @default.
- W4200014774 created "2021-12-31" @default.
- W4200014774 creator A5030739544 @default.
- W4200014774 creator A9999999999 @default.
- W4200014774 date "2021-12-09" @default.
- W4200014774 modified "2023-10-14" @default.
- W4200014774 title "Trehalose amide glycolipids as Mincle ligands: Towards new vaccine adjuvants" @default.
- W4200014774 doi "https://doi.org/10.26686/wgtn.17152082" @default.
- W4200014774 hasPublicationYear "2021" @default.
- W4200014774 type Work @default.
- W4200014774 citedByCount "0" @default.
- W4200014774 crossrefType "dissertation" @default.
- W4200014774 hasAuthorship W4200014774A5030739544 @default.
- W4200014774 hasAuthorship W4200014774A9999999999 @default.
- W4200014774 hasBestOaLocation W42000147741 @default.
- W4200014774 hasConcept C185592680 @default.
- W4200014774 hasConcept C203014093 @default.
- W4200014774 hasConcept C22222904 @default.
- W4200014774 hasConcept C2777863537 @default.
- W4200014774 hasConcept C2778439535 @default.
- W4200014774 hasConcept C2778452849 @default.
- W4200014774 hasConcept C55493867 @default.
- W4200014774 hasConcept C71240020 @default.
- W4200014774 hasConcept C86803240 @default.
- W4200014774 hasConceptScore W4200014774C185592680 @default.
- W4200014774 hasConceptScore W4200014774C203014093 @default.
- W4200014774 hasConceptScore W4200014774C22222904 @default.
- W4200014774 hasConceptScore W4200014774C2777863537 @default.
- W4200014774 hasConceptScore W4200014774C2778439535 @default.
- W4200014774 hasConceptScore W4200014774C2778452849 @default.
- W4200014774 hasConceptScore W4200014774C55493867 @default.
- W4200014774 hasConceptScore W4200014774C71240020 @default.
- W4200014774 hasConceptScore W4200014774C86803240 @default.
- W4200014774 hasLocation W42000147741 @default.
- W4200014774 hasLocation W42000147742 @default.
- W4200014774 hasOpenAccess W4200014774 @default.
- W4200014774 hasPrimaryLocation W42000147741 @default.
- W4200014774 hasRelatedWork W1976914524 @default.
- W4200014774 hasRelatedWork W1985297470 @default.
- W4200014774 hasRelatedWork W1994593926 @default.
- W4200014774 hasRelatedWork W2949825340 @default.
- W4200014774 hasRelatedWork W2950141370 @default.
- W4200014774 hasRelatedWork W3008011764 @default.
- W4200014774 hasRelatedWork W4200014774 @default.
- W4200014774 hasRelatedWork W4200455758 @default.
- W4200014774 hasRelatedWork W4381327146 @default.
- W4200014774 hasRelatedWork W2769781467 @default.
- W4200014774 isParatext "false" @default.
- W4200014774 isRetracted "false" @default.
- W4200014774 workType "dissertation" @default.