Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200015619> ?p ?o ?g. }
- W4200015619 endingPage "114891" @default.
- W4200015619 startingPage "114891" @default.
- W4200015619 abstract "The polysaccharides of the millenary mushroom Ganoderma lucidum (GL) have been shown for decades to present anti-tumor activities, but few studies evaluated its importance on cancer stem cells and EMT process. Cancer stem cells (CSC) drive the development of carcinoma and are also involved in cancer treatment failure, being a good target for treatment success. Also, the process of epithelial-mesenchymal transition (EMT) is involved in metastasis and cancer relapse. Besides that, the increasing incidence worldwide of oral squamous cell carcinoma (OSCC) became a public health issue with a high rate of metastasis and poor quality of life for patients during and after treatment.to evaluate G. lucidum polysaccharides (GLPS) in vitro effects on OSCC, focusing on hallmarks associated with tumorigenesis using the SCC-9, a squamous cells carcinoma lineage from the tongue.SCC-9 cells were treated in vitro for 72h with different GLPS concentrations. The controls cells were maintained with culture media only and cisplatin was used as treatment control. After the treatment period, the cells were evaluated.GLPS treatment changed cell morphology and granularity, delayed migration, decreased colony, and impaired sphere formation, thereby leading to a non-invasive and less proliferative behavior of tumoral cells. Additionally, GLPS downregulated CSC, EMT, and drug sensitivity (ABC) markers.These results show that the natural product GLPS has the potential to be an important ally for tongue squamous cell carcinoma treatment, bringing the millenary compound to modern therapy, providing a basis for future studies and the improvement of life quality for OSCC patients." @default.
- W4200015619 created "2021-12-31" @default.
- W4200015619 creator A5002921725 @default.
- W4200015619 creator A5010354440 @default.
- W4200015619 creator A5010625187 @default.
- W4200015619 creator A5023688474 @default.
- W4200015619 creator A5035672466 @default.
- W4200015619 creator A5049855228 @default.
- W4200015619 creator A5063396885 @default.
- W4200015619 creator A5086894694 @default.
- W4200015619 creator A5086995155 @default.
- W4200015619 date "2022-03-01" @default.
- W4200015619 modified "2023-10-16" @default.
- W4200015619 title "Ganoderma lucidum polysaccharides inhibit in vitro tumorigenesis, cancer stem cell properties and epithelial-mesenchymal transition in oral squamous cell carcinoma" @default.
- W4200015619 cites W1869447257 @default.
- W4200015619 cites W1906197125 @default.
- W4200015619 cites W1983961550 @default.
- W4200015619 cites W1984046836 @default.
- W4200015619 cites W1997755898 @default.
- W4200015619 cites W1998281248 @default.
- W4200015619 cites W1998375452 @default.
- W4200015619 cites W1999499820 @default.
- W4200015619 cites W2009745643 @default.
- W4200015619 cites W2012246297 @default.
- W4200015619 cites W2014691022 @default.
- W4200015619 cites W2023353726 @default.
- W4200015619 cites W2032608449 @default.
- W4200015619 cites W2042147507 @default.
- W4200015619 cites W2058763255 @default.
- W4200015619 cites W2062069198 @default.
- W4200015619 cites W2064566518 @default.
- W4200015619 cites W2071946741 @default.
- W4200015619 cites W2075757373 @default.
- W4200015619 cites W2081454449 @default.
- W4200015619 cites W2082483015 @default.
- W4200015619 cites W2082496950 @default.
- W4200015619 cites W2086062779 @default.
- W4200015619 cites W2087999409 @default.
- W4200015619 cites W2092414684 @default.
- W4200015619 cites W2097308038 @default.
- W4200015619 cites W2101405590 @default.
- W4200015619 cites W2125505694 @default.
- W4200015619 cites W2132820593 @default.
- W4200015619 cites W2136380412 @default.
- W4200015619 cites W2138240309 @default.
- W4200015619 cites W2142024216 @default.
- W4200015619 cites W2146376108 @default.
- W4200015619 cites W2148707387 @default.
- W4200015619 cites W2154907746 @default.
- W4200015619 cites W2160678012 @default.
- W4200015619 cites W2161215119 @default.
- W4200015619 cites W2232551922 @default.
- W4200015619 cites W2240026504 @default.
- W4200015619 cites W2251188790 @default.
- W4200015619 cites W2328653797 @default.
- W4200015619 cites W2331363863 @default.
- W4200015619 cites W2535385744 @default.
- W4200015619 cites W2543056808 @default.
- W4200015619 cites W2588554400 @default.
- W4200015619 cites W2592828140 @default.
- W4200015619 cites W2594538327 @default.
- W4200015619 cites W2605570494 @default.
- W4200015619 cites W2606001457 @default.
- W4200015619 cites W2620260752 @default.
- W4200015619 cites W2727463864 @default.
- W4200015619 cites W2750201210 @default.
- W4200015619 cites W2767247332 @default.
- W4200015619 cites W2769263042 @default.
- W4200015619 cites W2771477087 @default.
- W4200015619 cites W2786843484 @default.
- W4200015619 cites W2794231728 @default.
- W4200015619 cites W2798231099 @default.
- W4200015619 cites W2811210439 @default.
- W4200015619 cites W2917968580 @default.
- W4200015619 cites W2920395851 @default.
- W4200015619 cites W2926136640 @default.
- W4200015619 cites W2937766145 @default.
- W4200015619 cites W2943830014 @default.
- W4200015619 cites W2962993133 @default.
- W4200015619 cites W2969312869 @default.
- W4200015619 cites W2977558826 @default.
- W4200015619 cites W2987132227 @default.
- W4200015619 cites W2989941288 @default.
- W4200015619 cites W2995166262 @default.
- W4200015619 cites W3004130357 @default.
- W4200015619 cites W3004470483 @default.
- W4200015619 cites W3005997435 @default.
- W4200015619 cites W3007147097 @default.
- W4200015619 cites W3010250047 @default.
- W4200015619 cites W3010316676 @default.
- W4200015619 cites W3011444063 @default.
- W4200015619 cites W3015112684 @default.
- W4200015619 cites W3025311015 @default.
- W4200015619 cites W3034134838 @default.
- W4200015619 cites W3047954565 @default.
- W4200015619 cites W3081272699 @default.
- W4200015619 cites W3093572193 @default.
- W4200015619 cites W3098662023 @default.