Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200015847> ?p ?o ?g. }
- W4200015847 abstract "Abstract Global healthcare systems continue to be challenged by the COVID-19 pandemic, and there is a need for clinical assays that can both help to optimize resource allocation and accelerate the development and evaluation of new therapies. Here, we present a multiplex proteomic panel assay for the assessment of disease severity and outcome prediction in COVID-19. The assay quantifies 50 peptides derived from 30 COVID-19 severity markers in a single measurement using analytical flow rate liquid chromatography and multiple reaction monitoring (LC-MRM), on equipment that is broadly available in routine and regulated analytical laboratories. We demonstrate accurate classification of COVID-19 severity in patients from two cohorts. Furthermore, the assay outperforms established risk assessments such as SOFA and APACHE II in predicting survival in a longitudinal COVID-19 cohort. The prognostic value implies its use for support of clinical decisions in settings with overstrained healthcare resources e.g. to optimally allocate resources to severely ill individuals with high chance of survival. It can furthermore be helpful for monitoring of novel therapies in clinical trials." @default.
- W4200015847 created "2021-12-31" @default.
- W4200015847 creator A5017401288 @default.
- W4200015847 creator A5027744537 @default.
- W4200015847 creator A5042425936 @default.
- W4200015847 creator A5046636813 @default.
- W4200015847 creator A5046830619 @default.
- W4200015847 creator A5048502650 @default.
- W4200015847 creator A5049376058 @default.
- W4200015847 creator A5050894150 @default.
- W4200015847 creator A5055096331 @default.
- W4200015847 creator A5062977367 @default.
- W4200015847 creator A5064767405 @default.
- W4200015847 creator A5067400001 @default.
- W4200015847 creator A5067716705 @default.
- W4200015847 creator A5067796654 @default.
- W4200015847 creator A5074607200 @default.
- W4200015847 creator A5075257395 @default.
- W4200015847 creator A5087602254 @default.
- W4200015847 creator A5091301473 @default.
- W4200015847 date "2021-12-05" @default.
- W4200015847 modified "2023-10-08" @default.
- W4200015847 title "A multiplex protein panel assay determines disease severity and is prognostic about outcome in COVID-19 patients" @default.
- W4200015847 cites W1965092590 @default.
- W4200015847 cites W1965693707 @default.
- W4200015847 cites W1980103804 @default.
- W4200015847 cites W1991355901 @default.
- W4200015847 cites W2056467018 @default.
- W4200015847 cites W2068481474 @default.
- W4200015847 cites W2110065044 @default.
- W4200015847 cites W2139751505 @default.
- W4200015847 cites W2141091417 @default.
- W4200015847 cites W2344158997 @default.
- W4200015847 cites W2460147934 @default.
- W4200015847 cites W2738829847 @default.
- W4200015847 cites W2947559922 @default.
- W4200015847 cites W2965512201 @default.
- W4200015847 cites W2979236711 @default.
- W4200015847 cites W2992970386 @default.
- W4200015847 cites W2998913628 @default.
- W4200015847 cites W3005905858 @default.
- W4200015847 cites W3006224151 @default.
- W4200015847 cites W3014524604 @default.
- W4200015847 cites W3021191129 @default.
- W4200015847 cites W3028711203 @default.
- W4200015847 cites W3031410640 @default.
- W4200015847 cites W3034205263 @default.
- W4200015847 cites W3042129837 @default.
- W4200015847 cites W3046588153 @default.
- W4200015847 cites W3087855548 @default.
- W4200015847 cites W3091839106 @default.
- W4200015847 cites W3096164104 @default.
- W4200015847 cites W3109182269 @default.
- W4200015847 cites W3114171035 @default.
- W4200015847 cites W3117267883 @default.
- W4200015847 cites W3118949855 @default.
- W4200015847 cites W3138817412 @default.
- W4200015847 cites W3152531891 @default.
- W4200015847 cites W3170549259 @default.
- W4200015847 cites W3171623624 @default.
- W4200015847 cites W3174179740 @default.
- W4200015847 cites W3175827164 @default.
- W4200015847 cites W3182801282 @default.
- W4200015847 cites W3185155098 @default.
- W4200015847 cites W3188291121 @default.
- W4200015847 cites W3193948535 @default.
- W4200015847 cites W3199849883 @default.
- W4200015847 cites W3206181818 @default.
- W4200015847 cites W3206648736 @default.
- W4200015847 cites W3216903445 @default.
- W4200015847 cites W4225505755 @default.
- W4200015847 cites W4225854071 @default.
- W4200015847 cites W4226181138 @default.
- W4200015847 doi "https://doi.org/10.1101/2021.12.03.21267253" @default.
- W4200015847 hasPublicationYear "2021" @default.
- W4200015847 type Work @default.
- W4200015847 citedByCount "0" @default.
- W4200015847 crossrefType "posted-content" @default.
- W4200015847 hasAuthorship W4200015847A5017401288 @default.
- W4200015847 hasAuthorship W4200015847A5027744537 @default.
- W4200015847 hasAuthorship W4200015847A5042425936 @default.
- W4200015847 hasAuthorship W4200015847A5046636813 @default.
- W4200015847 hasAuthorship W4200015847A5046830619 @default.
- W4200015847 hasAuthorship W4200015847A5048502650 @default.
- W4200015847 hasAuthorship W4200015847A5049376058 @default.
- W4200015847 hasAuthorship W4200015847A5050894150 @default.
- W4200015847 hasAuthorship W4200015847A5055096331 @default.
- W4200015847 hasAuthorship W4200015847A5062977367 @default.
- W4200015847 hasAuthorship W4200015847A5064767405 @default.
- W4200015847 hasAuthorship W4200015847A5067400001 @default.
- W4200015847 hasAuthorship W4200015847A5067716705 @default.
- W4200015847 hasAuthorship W4200015847A5067796654 @default.
- W4200015847 hasAuthorship W4200015847A5074607200 @default.
- W4200015847 hasAuthorship W4200015847A5075257395 @default.
- W4200015847 hasAuthorship W4200015847A5087602254 @default.
- W4200015847 hasAuthorship W4200015847A5091301473 @default.
- W4200015847 hasBestOaLocation W42000158471 @default.
- W4200015847 hasConcept C126322002 @default.
- W4200015847 hasConcept C143998085 @default.
- W4200015847 hasConcept C160735492 @default.