Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200017038> ?p ?o ?g. }
- W4200017038 abstract "Long noncoding RNA H19 (H19) is an imprinting gene with only maternal expression that is involved in regulating different processes in various types of cells. Previous studies have shown that abnormal H19 expression is involved in many pathological processes, such as cancer, mainly through sponging miRNAs, interacting with proteins, or regulating epigenetic modifications. Accumulating evidence has shown that several oncogenic signaling pathways lead to carcinogenesis. Recently, the regulatory relationship between H19 and oncogenic signaling pathways in various types of cancer has been of great interest to many researchers. In this review, we discussed the key roles of H19 in cancer development and progression via its regulatory function in several oncogenic signaling pathways, such as PI3K/Akt, canonical Wnt/β-catenin, canonical NF-κB, MAPK, JAK/STAT and apoptosis. These oncogenic signaling pathways regulated by H19 are involved in cell proliferation, proliferation, migration and invasion, angiogenesis, and apoptosis of various cancer cells. This review suggests that H19 may be a novel therapeutic target for cancers treatment by regulating oncogenic signaling pathways." @default.
- W4200017038 created "2021-12-31" @default.
- W4200017038 creator A5021659358 @default.
- W4200017038 creator A5031246081 @default.
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- W4200017038 creator A5052429576 @default.
- W4200017038 creator A5062278942 @default.
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- W4200017038 creator A5081544419 @default.
- W4200017038 creator A5083238725 @default.
- W4200017038 creator A5042181207 @default.
- W4200017038 date "2021-12-16" @default.
- W4200017038 modified "2023-10-15" @default.
- W4200017038 title "Long Noncoding RNA H19: A Novel Therapeutic Target Emerging in Oncology Via Regulating Oncogenic Signaling Pathways" @default.
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