Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200017946> ?p ?o ?g. }
- W4200017946 endingPage "385" @default.
- W4200017946 startingPage "371" @default.
- W4200017946 abstract "Double-negative (DN) T cells are present at relatively low frequencies in human peripheral blood, and are characterized as expressing the alpha-beta or gamma-delta T-cell receptor (TCR), but not the CD4 nor the CD8 co-receptors. Despite their low frequencies, these cells are potent producers of cytokines and, thus, are key orchestrators of immune responses. DN T cells were initially associated with induction of peripheral immunological tolerance and immunomodulatory activities related to disease prevention. However, other studies demonstrated that these cells can also display effector functions associated with pathology development. This apparent contradiction highlighted the heterogeneity of the DN T-cell population. Here, we review phenotypic and functional characteristics of DN T cells, emphasizing their role in human diseases. The need for developing biomarkers to facilitate the translation of studies from animal models to humans will also be discussed. Finally, we will examine DN T cells as promising therapeutic targets to prevent or inhibit human disease development." @default.
- W4200017946 created "2021-12-31" @default.
- W4200017946 creator A5005281876 @default.
- W4200017946 creator A5017399345 @default.
- W4200017946 creator A5023000862 @default.
- W4200017946 date "2022-01-05" @default.
- W4200017946 modified "2023-10-03" @default.
- W4200017946 title "Double‐negative T cells: Setting the stage for disease control or progression" @default.
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