Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200032005> ?p ?o ?g. }
- W4200032005 abstract "Largemouth bass virus (LMBV) is one of the most devastating viral pathogens in farmed Largemouth bass. Aptamers are novel molecule probes and have been widely applied in the field of efficient therapeutic and diagnostic agents development. LMBV-infected fathead minnow cells (LMBV-FHM) served as target cells in this study, and three DNA aptamers (LBVA1, LBVA2, and LBVA3) were generated against target cells by SELEX technology. The selected aptamers could specifically bind to LMBV-FHM cells, with rather high calculated dissociation constants (Kd) of 890.09, 517.22, and 249.31 nM for aptamers LBVA1, LBVA2, and LBVA3, respectively. Three aptamers displayed efficient antiviral activities in vitro. It indicates that the selected aptamers have great potentials in developing efficient anti-viruses treatments. The targets of aptamers LBVA1, LBVA2, and LBVA3 could be membrane proteins on host cells. The targets of aptamers (LBVA1, LBVA2, and LBVA3) come out on the cells surface at 8, 10, 8 h post-infection. As novel molecular probes for accurate recognition, aptamer LBVA3 could detect LMBV infection in vitro and in vivo, it indicates that the selected aptamers could be applied in the development of rapid detective technologies, which are characterized by high sensitivity, accuracy, and easy operation." @default.
- W4200032005 created "2021-12-31" @default.
- W4200032005 creator A5004826834 @default.
- W4200032005 creator A5014394467 @default.
- W4200032005 creator A5019324414 @default.
- W4200032005 creator A5037281969 @default.
- W4200032005 creator A5051062987 @default.
- W4200032005 creator A5074577650 @default.
- W4200032005 creator A5091627438 @default.
- W4200032005 date "2021-12-17" @default.
- W4200032005 modified "2023-10-15" @default.
- W4200032005 title "Selection and Characterization of ssDNA Aptamers Targeting Largemouth Bass Virus Infected Cells With Antiviral Activities" @default.
- W4200032005 cites W1896124845 @default.
- W4200032005 cites W1980844451 @default.
- W4200032005 cites W1993150610 @default.
- W4200032005 cites W2011833640 @default.
- W4200032005 cites W2014326137 @default.
- W4200032005 cites W2020855876 @default.
- W4200032005 cites W2034037652 @default.
- W4200032005 cites W2043889858 @default.
- W4200032005 cites W2046931419 @default.
- W4200032005 cites W2056824511 @default.
- W4200032005 cites W2060142234 @default.
- W4200032005 cites W2060544757 @default.
- W4200032005 cites W2061507639 @default.
- W4200032005 cites W2079377900 @default.
- W4200032005 cites W2079606233 @default.
- W4200032005 cites W2089108066 @default.
- W4200032005 cites W2109169619 @default.
- W4200032005 cites W2162506288 @default.
- W4200032005 cites W2196532209 @default.
- W4200032005 cites W2282276091 @default.
- W4200032005 cites W2309891744 @default.
- W4200032005 cites W2344162385 @default.
- W4200032005 cites W2345588031 @default.
- W4200032005 cites W2494986147 @default.
- W4200032005 cites W2566920630 @default.
- W4200032005 cites W2604540918 @default.
- W4200032005 cites W2793189046 @default.
- W4200032005 cites W2901989889 @default.
- W4200032005 cites W2917596324 @default.
- W4200032005 cites W2920439209 @default.
- W4200032005 cites W2922077152 @default.
- W4200032005 cites W2932505969 @default.
- W4200032005 cites W2948173880 @default.
- W4200032005 cites W2972309774 @default.
- W4200032005 cites W2972404300 @default.
- W4200032005 cites W2989207132 @default.
- W4200032005 cites W3014512067 @default.
- W4200032005 cites W3023614380 @default.
- W4200032005 cites W3033207466 @default.
- W4200032005 cites W3036136848 @default.
- W4200032005 cites W3092831501 @default.
- W4200032005 cites W3121380856 @default.
- W4200032005 doi "https://doi.org/10.3389/fmicb.2021.785318" @default.
- W4200032005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34975807" @default.
- W4200032005 hasPublicationYear "2021" @default.
- W4200032005 type Work @default.
- W4200032005 citedByCount "6" @default.
- W4200032005 countsByYear W42000320052022 @default.
- W4200032005 countsByYear W42000320052023 @default.
- W4200032005 crossrefType "journal-article" @default.
- W4200032005 hasAuthorship W4200032005A5004826834 @default.
- W4200032005 hasAuthorship W4200032005A5014394467 @default.
- W4200032005 hasAuthorship W4200032005A5019324414 @default.
- W4200032005 hasAuthorship W4200032005A5037281969 @default.
- W4200032005 hasAuthorship W4200032005A5051062987 @default.
- W4200032005 hasAuthorship W4200032005A5074577650 @default.
- W4200032005 hasAuthorship W4200032005A5091627438 @default.
- W4200032005 hasBestOaLocation W42000320051 @default.
- W4200032005 hasConcept C104317684 @default.
- W4200032005 hasConcept C122682173 @default.
- W4200032005 hasConcept C128972844 @default.
- W4200032005 hasConcept C153911025 @default.
- W4200032005 hasConcept C159047783 @default.
- W4200032005 hasConcept C185592680 @default.
- W4200032005 hasConcept C202751555 @default.
- W4200032005 hasConcept C2522874641 @default.
- W4200032005 hasConcept C55493867 @default.
- W4200032005 hasConcept C67705224 @default.
- W4200032005 hasConcept C86803240 @default.
- W4200032005 hasConceptScore W4200032005C104317684 @default.
- W4200032005 hasConceptScore W4200032005C122682173 @default.
- W4200032005 hasConceptScore W4200032005C128972844 @default.
- W4200032005 hasConceptScore W4200032005C153911025 @default.
- W4200032005 hasConceptScore W4200032005C159047783 @default.
- W4200032005 hasConceptScore W4200032005C185592680 @default.
- W4200032005 hasConceptScore W4200032005C202751555 @default.
- W4200032005 hasConceptScore W4200032005C2522874641 @default.
- W4200032005 hasConceptScore W4200032005C55493867 @default.
- W4200032005 hasConceptScore W4200032005C67705224 @default.
- W4200032005 hasConceptScore W4200032005C86803240 @default.
- W4200032005 hasLocation W42000320051 @default.
- W4200032005 hasLocation W42000320052 @default.
- W4200032005 hasLocation W42000320053 @default.
- W4200032005 hasLocation W42000320054 @default.
- W4200032005 hasOpenAccess W4200032005 @default.
- W4200032005 hasPrimaryLocation W42000320051 @default.
- W4200032005 hasRelatedWork W2392306680 @default.
- W4200032005 hasRelatedWork W2918405227 @default.