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- W4200055433 abstract "This review addresses pharmacological, structural and functional relationships among H2-histamine receptors and H1-histamine receptors in the mammalian heart. The role of both receptors in the regulation of force and rhythm, including their electrophysiological effects on the mammalian heart, will then be discussed in context. The potential clinical role of cardiac H2-histamine-receptors in cardiac diseases will be examined. The use of H2-histamine receptor agonists to acutely increase the force of contraction will be discussed. Special attention will be paid to the potential role of cardiac H2-histamine receptors in the genesis of cardiac arrhythmias. Moreover, novel findings on the putative role of H2-histamine receptor antagonists in treating chronic heart failure in animal models and patients will be reviewed. Some limitations in our biochemical understanding of the cardiac role of H2-histamine receptors will be discussed. Recommendations for further basic and translational research on cardiac H2-histamine receptors will be offered. We will speculate whether new knowledge might lead to novel roles of H2-histamine receptors in cardiac disease and whether cardiomyocyte specific H2-histamine receptor agonists and antagonists should be developed." @default.
- W4200055433 created "2021-12-31" @default.
- W4200055433 creator A5001439184 @default.
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- W4200055433 creator A5038198504 @default.
- W4200055433 creator A5049919699 @default.
- W4200055433 creator A5064946477 @default.
- W4200055433 date "2021-12-20" @default.
- W4200055433 modified "2023-09-30" @default.
- W4200055433 title "The Roles of Cardiovascular H2-Histamine Receptors Under Normal and Pathophysiological Conditions" @default.
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